The one abnormality constantly found in hemophilia is an inability of the blood to coagulate in a normal manner. This defect is demonstrable usually by a prolonged clotting time, which in turn determines the various manifestations of the disease. Further understanding of this disease depends, therefore, upon knowledge of the cause of the prolonged clotting time. Most investigations of the blood...

Following an injury to the walls of a blood vessel, platelet aggregation and blood coagulation are induced. Through a series of enzymatic and biochemical interactions, a blood clot is formed. Using ordinary differential equations with mass action and Michaelis-Menton kinetics to describe these interactions and computer programs like Fortran and Matlab, we are able to model blood clot formation ...

The activity of blood clotting factors has been investigated in cerebrospinal fluid. No cephalin-like activity was found in cerebrospinal fluid but prothrombin activity averaged about 0.5% of normal plasma activity. The activity of factor VII was negligible in almost all cases. The activity of antihaemophilic factors showed great variation but in the majority of cases it did not exceed 1% of no...

BACKGROUND Hemorrhage and coagulopathy are major contributors to death after trauma. The contribution of red blood cells (RBCs) in correcting coagulopathy is poorly understood. Current methods of measuring coagulopathy may fail to accurately characterize in vivo clotting. We aimed to determine the effect of RBCs on clotting parameters by comparing resuscitation regimens containing RBCs and plas...

We have studied the effects of both impaired prothrombin activation and direct inhibition of thrombin on the platelet release reaction in clotting blood to determine the role of thrombin in this process. In blood from two patients with congenital Factor V deficiency, prothrombin activation during spontaneous in vitro clotting was delayed and decreased. Secretion of platelet Factor 4 was also de...

The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations and the latter comprise both thresholdlimited behaviors and binary states (presence/absence of a chemical). Whereas previous blood-clotting models used only continuous dynamics ...

This paper describes microfluidic experiments with human blood plasma and numerical simulations to determine the role of fluid flow in the regulation of propagation of blood clotting. We demonstrate that propagation of clotting can be regulated by different mechanisms depending on the volume-to-surface ratio of a channel. In small channels, propagation of clotting can be prevented by surface-bo...

BACKGROUND Haemorrhage remains the greatest threat to life on the battlefield, accounting for half of all deaths. Over the past decade the US army has widely studied new technologies for stopping sever haemorrhages and has introduced an effective zeolite based haemostatic agent. In this paper the bio-stimulatory effect of burned radioactive lantern mantles powder as well as two minerals; benton...

The prevention of extracorporeal clotting during hemodialysis maximizes the effectiveness of treatment by maintaining patency in the dialyzer blood compartment and thereby obviating several important consequences. For example, clotting leads directly to blood loss, as much as 200-300 ml for each episode, depending on the total volume of the extracorporeal circuit. In addition, clotting reduces ...

Autoerythrocyte sensitization syndrome CABS) is a rare purpuric disorder of women characterized by inflammatory and painful ecchymotic lesions unrelated to blood clotting or vascular abnormalities. Gastrointestinal bleeding, hematuria, headache or syncopal attacks may also be observed. Our patient is a 33-year-old woman presenting with recurrent severe painful ecchymotic lesions on both lo...