Circulating blood platelets are specialized cells that prevent bleeding and minimize blood vessel injury. Large progenitor cells in the bone marrow called megakaryocytes (MKs) are the source of platelets. MKs release platelets through a series of fascinating cell biological events. During maturation, they become polyploid and accumulate massive amounts of protein and membrane. Then, in a cytosk...

I ‘ HAS LONG BEEN KNOWN that blood platelets are isoantigenic.’ Serum isoantibodies reacting with platelets have been repeatedly demonstrated in 1)citieflts ‘ho have received multiple blood transfusions, and in multiparous vomen.’’4 The iiicidence of isoimmunity to blood platelets in niultitransfused iNitients has been studied mainly by the the anti-human globulin consumption,’2 the indirect Co...

Blood 5-hydroxytryptamine levels were reduced during migraine attacks in patients who had not taken any drugs but the aggregation responses to 5-hydroxytryptamine of the blood platelets from these patients were similar to responses of platelets from migrainous subjects between attacks. This confirms earlier findings that a permanent difference exists in the behaviour of platelets from migrainou...

Background: The origin and function of human leukocyte antigen (HLA) class I molecules on platelets are still highly arguable. Given the differences in the results of the previous studies in this regard, the lack of research in recent years, and the clinical importance of HLA class I molecules, the absorption capacity of platelets for soluble HLA class I molecules was studied in this investigat...

• A rapid, reproducible method of determiniEg the presence and relative amounts of adhesive and aggregated blood elements in the blood has recently been developed in this laboratory.The method involves measuring the pressure required to force blood at a constant rate through a standardized screen with multiple openings 20 micra square and 20 micra deep. This pressure has been named "screen nitr...

• A rapid, reproducible method of determiniEg the presence and relative amounts of adhesive and aggregated blood elements in the blood has recently been developed in this laboratory.The method involves measuring the pressure required to force blood at a constant rate through a standardized screen with multiple openings 20 micra square and 20 micra deep. This pressure has been named "screen nitr...

Peripheral blood platelet parameters were studied in 53 apparently healthy female volunteers living the city of Kropyvnytskyi, Kirovohrad region. 2 groups formed: main group received biologically active supplement (BAD) mumijo once a day for 30 days, and control did not receive this drug. The content platelets (PLT), mean volume (MPV), relative width distribution by volume, i.e. heterogeneity i...

Posttransfusion purpura typically occurs in PL negative blood recipients who have been previously immunized to the PL antigen. Following transfusion. severe thrombocytopenia develops with the formation of anti-PL . Since the patients’ platelets lack the PL antigen. one would not expect this antibody to destroy autologous platelets. In this study we show that PL antigen exists in stored blood an...

Platelets are anuclear blood cells whose function is to form blood clots when we injure ourselves, to prevent excessive blood loss. Thrombocytopenia is a relative low number of platelets in the blood. Thrombocytopenia has several possible causes, including the trapping of platelets in spleen, reduced production of platelets and increased breakdown of platelets. Some examples of an increase in p...