Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine which controls the differentiation and growth of hematopoietic cells in the bone marrow. We report a severe aplastic anemia (SAA) patient with false-negative 99mTc sodium phytate bone marrow imaging findings under concurrent G-CSF therapy. The first bone marrow imaging showed a normal bone marrow activity. However, the bo...

Background: Pathological lesions usually replace normal components of the vertebral bone marrow including benign and malignant lesions, as well as, fractures, inflammatory and degenerative marrow process. DWI is considered to be a potential tool which can help in characterization of different bone marrow lesions by exploiting the structural differences of biologic tissue. Objective: To evaluate...

BACKGROUND Disseminated tumor cells (DTCs) in the bone marrow may exist in a dormant state for extended periods of time, maintaining the ability to proliferate upon activation, engraft at new sites, and form detectable metastases. However, understanding of the behavior and biology of dormant breast cancer cells in the bone marrow niche remains limited, as well as their potential involvement in ...

background: hematological abnormalities are a common complication of hiv infection and occur in all stages of the infection. these abnormalities increase as the disease advances. we aimed to evaluate the diagnostic utility of bone marrow sampling in hiv-positive patients. methods: 40 hiv-infected individuals were screened for hematological abnormalities. investigations such as iron studies, hem...

We present a 30-year-old man admitted with generalized cutaneous lesions, fever and cough. Examination of skin biopsies of a papular lesion revealed dense neutrophilic infiltration of the upper dermis, so these lesions were diagnosed as neutrophilic dermatosis. Peripheral blood examination and bone marrow findings confirmed the diagnosis of myelodysplastic syndrome with excess blasts. The cutan...

OBJECTIVE This study was designed to determine whether diffusion-weighted imaging (DWI) with sensitivity encoding (SENSE) could detect bone marrow involvement in patients with cranial bone marrow (CBM) metastases. DWI results obtained were compared with T1-weighted imaging (T1WI) findings. MATERIALS AND METHODS DWI with sensitivity encoding (SENSE; b value = 1,000) was performed consecutively...

The use of biologic augmentation following microfracture for symptomatic cartilage defects the knee with osseous involvement shows encouraging results. Bone marrow aspirate concentrate provides growth factors to injury site, such as vascular endothelial factor, platelet-derived transforming factor-βa, and bone morphogenetic proteins in addition mesenchymal stem cells present concentrate. Cellul...

BACKGROUND This study characterized a novel rabbit model of subchondral bone bruise and investigated the intervening effect of calcitonin. METHODS Bone bruise was implemented via controlled free-fall counterpoise on the medial tibial subchondral bone of 5-month-old New Zealand rabbits, with 3, 2.5, or 2 Joules of energy. Subsequent subchondral bone bruise was characterized via magnetic resona...