Cadmium (Cd) is a heavy metal that exists ubiquitously in the environment, and it interacts with essential elements such as zinc, copper, iron, and calcium (Ca). Particularly, Cd interferes with Ca and vitamin D metabolism in bone kidney and intestine. The interaction between Cd and Ca in bone, intestine, and kidney may result in the disorder of bone metabolism. On the other hand, pregnancy and...

Reduction of mechanical stress on bone inhibits osteoblast-mediated bone formation and accelerates osteoclast-mediated bone resorption, and leads to what has been called disuse osteoporosis. Prolonged therapeutic bed rest, immobilization due to motor paralysis from injury of the central nervous system or peripheral nerves, application of cast to treat fractures, a common causes of disuse osteop...

BACKGROUND Bone metabolism disorders in hemodialysed patients (HD) involve several humoral factors, of which PTH plays the central role. Leptin is usually found increased in renal failure and its link with bone metabolism has not been elucidated. We investigated the BMD and bone metabolism in association with serum PTH, 25OHD3 and leptin in HD patients. METHODS We measured bone alkaline phosp...

OBJECTIVE This study was designed to prospectively examine differential effects of sustained "high" and "low" serum prolactin levels on bone mineral density and peripheral markers of bone metabolism. METHOD A dual-energy X-ray absorptiometer was used to measure bone mineral density. Peripheral markers of bone formation and resorption were used to measure bone metabolism in 14 Caucasian female...

IN THE LAST YEARS THERE HAS BEEN AN INCREASED AWARENESS REGARDING THE ALTERATIONS OF BONE METABOLISM AS A COMMON COMPLICATION OF CHRONIC LIVER THAT OCCURS REGARDLESS OF THE ETIOLOGY: alcoholic, viral, autoimmune, whether or not associated with cholestasis.The aim of this paper was to summarize the current understanding of bone metabolism and to point out the new discoveries that have been made ...

Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic disorders. Based on in vitro, in vivo, and clinical studies, this review explains ...

osteoporosis, characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enlarged bone fragility and a consequent increase in fracture risk is a leading cause of morbidity and mortality in elderly people. the mortality rate in elderly persons with hip fracture approaches 20%. half of them will be disabled in the remained life. iranian multicenter osteoporosis ...

Birds have a unique bone physiology, due to the demands placed on them through egg production. In particular their medullary bone serves as a source of calcium for eggshell production during lay and undergoes continuous and rapid remodelling. We take advantage of the fact that bone traits have diverged massively during chicken domestication to map the genetic basis of bone metabolism in the chi...

Background: We aimed to investigate the short-term effects of adrenocorticotropic hormone (ACTH) treatment on adrenal pathway and bone metabolism in patients with epileptic encephalopathy.
 Methods: Two groups 16 controls were formed. Before treatment, all tested for metabolism. Twenty doses ACTH therapy given patient group over 3 months. The tests repeated 1 month after end treatment.&#x0...