Breast cancer (BC) metastases to bone disrupt the balance between osteoblasts and osteoclasts, leading excessive resorption. We identified a novel subpopulation of with tumor-inhibitory properties, called educated (EOs). Here we sought examine effect EOs on osteoclastogenesis during tumor progression. hypothesized that affect osteoclast development in bone-tumor niche, suppressed pre-osteoclast...

In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The AvB3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in tumor cell invasion and osteoclast-mediated bone resorption. Here, we hypothesized that the therapeutic targ...

background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...

This study investigates the optimal external parameters for using an ultrasound applicator for treating bone tumors. This system utilized spherically arranged applicators such as scanned focused ultrasound, and spherically focused multielement applicators. The power deposition pattern is modeled as geometric gain with exponential attenuation. The specific absorption rate ratio (SARR) criteria h...

BACKGROUND Bone cancer pain has a disruptive effect on the cancer patient's quality of life. Although ginsenosides have been used as traditional medicine in Eastern Medicine, the effect on bone cancer pain has not been thoroughly studied. The aim of this study was to determine whether ginsenosides may alter the bone cancer pain at the spinal level. METHODS NCTC 2472 tumor cells (2.5 × 10(5)) ...

Hepatocellular carcinoma is the most common primary liver tumor. usually makes metastasis to bones. Prognosis of bone hepatocellular becoming better with early diagnosis and improvements in treatment modalities. As survival increases, faced more. However, humerus very rare. Bone may result symptoms pathologic fractures. worsens patients’ quality life. Early proper are important. Herein we repor...

Bone Tumor Suppression Magnetic bone cement incorporating magnetically soft zinc ferrite nanoparticles and aligned in a direct current magnetic field realized exceptionally high heating power live animals under clinically safe parameters for hyperthermia. of osteosarcoma rabbits by hyperthermia substantially enhances survival rate. More details can be found article number 2104626 Shuli He, Qing...

Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as th...

Giant cell tumor (GCT) of the bone also known as osteoclastoma typically arises from meta-epiphyseal region long and comprises 5% all tumors 20% benign tumors. Understanding pathogenesis is key to successful systemic therapy with denosumab, a RANK-ligand inhibitor. In this context, we report seven GCT bone-treated denosumab radiotherapy cases diverse clinical presentation our institute, NRS Med...

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