Background: A better understanding of how bone mineral density and vitamin D levels are associated with femoralneck and intertrochanteric hip fractures may help inform healthcare providers. We asked: 1) In patients age ≥ 55 years,is there a difference in quantitative ultrasound of the heel (QUS) t-score between patients with fractures of the femoralneck and those with fractures of the intertroc...

INTRODUCTION: Prediction of bone fracture goes beyond bone mineral density measurement. The quality of bone matrix is instrumental in providing fracture resistance to bone. Thus assessment of bone quality is critical to understanding bone fracture. Reference point indentation (RPI) purports to measure bone matrix quality in vivo and has been shown to separate fracture and non-fracture groups wi...

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass....

demineralized bone matrix has been successfully commercialized as an alternative bone graft material that not only can function as filler but also as an osteoinductive graft. numerous studies have confirmed its beneficial use in clinical practice. heterotopic ossification after internal fixation combined with the use of demineralized bone matrix has not been widely reported. in this paper we de...

a 3-year-old wild gray wolf was referred to the department of veterinary clinical sciences of shirazuniversity with a history of car accident. the radiographic examination showed supracondylar distal femoralfracture in right leg. the wolf was pre-medicated by acepromazine followed by induction of anesthesia usinga combination of diazepam and ketamine. anesthesia was maintained by halothane. the...

Fracture healing is a complex regenerative process. Although the histology and general mechanism of repair process are already clear and well established, much remains to be understood about the process of bone healing. The source of the cells that initiate fracture repair are unclear. It is thoght that fracture repair is initiated by mesenchymal progenitor cells (MPCs) which undergo differenti...

Growth hormone and insulin-like growth factor-1 (IGF-1) are essential for the achievement of normal longitudinal bone growth and bone mass. Preclinical studies using various knockout models have shown that both endocrine (mostly liver-derived) IGF-1 and bone-derived IGF-1 contribute to normal longitudinal skeletal growth and cortical bone size. Since bone size is an important determinant of bon...

Two case-control studies were designed to investigate the contribution of the geometry and bone mineral density (BMD) of the proximal femur to bone strength in Japanese elderly women. We also investigated whether clinical CT is useful to assess the risk of hip fracture. Subjects in the neck fracture study included 20 Japanese women with neck fracture (age: mean+/-SD; 80.1+/-4.5 years old) and 2...

Vitamin D deficiency is a widespread medical condition that plays a major role in human bone health. Fracture susceptibility in the context of low vitamin D has been primarily associated with defective mineralization of collagenous matrix (osteoid). However, bone's fracture resistance is due to toughening mechanisms at various hierarchical levels ranging from the nano- to the microstructure. Th...

PURPOSE This study examined whether multidetector computed tomography (CT) is superior to bone scintigraphy for diagnosis of an occult scaphoid fracture. METHODS AND MATERIALS In a study period of 22 months, 100 consecutive patients with a clinically suspected scaphoid fracture and no fracture on scaphoid radiographs, were evaluated with CT within 24 hours after injury and bone scintigraphy b...