BACKGROUND Alterations in adrenergic receptor densities can potentially contribute to myocardial dysfunction. Their relevance to myocardial hibernation in humans is unknown. METHODS AND RESULTS Accordingly, 22 transmural myocardial biopsies were obtained in 11 patients with ischemic ventricular dysfunction during bypass surgery, guided by transesophageal echocardiography. Patients underwent d...

We propose a framework which ports Dirichlet Gaussian mixture model (DPGMM) based labels to deep neural network (DNN). The DNN is used to extract a low-dimensional unsupervised speech representation, named as unsupervised bottleneck feature (uBNF), which captures considerable information for sound cluster discrimination. We investigate the performance of uBNF in query-by-example spoken term det...

A common belief in designing deep autoencoders (AEs), a type of unsupervised neural network, is that bottleneck required to prevent learning the identity function. Learning function renders AEs useless for anomaly detection. In this work, we challenge limiting and investigate value non-bottlenecked AEs. The can be removed two ways: (1) overparameterising latent layer, (2) introducing skip conne...

This work compared the effect of challenge with Vibrio tapetis, the etiologic agent of brown ring disease (BRD) in clams, and other bacterial strains on defence-related factors in four bivalve species: Ruditapes philippinarum (highly susceptible to BRD), R. decussatus (slightly susceptible to BRD), Mercenaria mercenaria and Crassostrea virginica (both non-susceptible to BRD). Results show that ...

Bilateral renal denervation (BRD) has been shown to reduce hypertension and improve renal function in both human and experimental studies. We hypothesized that chronic intervention with BRD may also attenuate renal injury and fibrosis in diabetic nephropathy. This hypothesis was examined in a female streptozotocin-induced diabetic (mRen-2)27 rat (TGR) shown to capture the cardinal features of h...

Brown Ring Disease (BRD) is a bacterial disease caused by the pathogen, Vibrio tapetis. The disease induces formation of a brown deposit on inner shell of the Manila clam, Ruditapes philippinarum. Development of this disease is correlated with a decrease in the condition index of infected clams. Experiments were conduced in order to assess the effect of the development of BRD on two parameters ...

BACKGROUND Bovine respiratory disease (BRD) is 1 of the 2 most important causes of morbidity and mortality in dairy calves. Surprisingly, field data are scant concerning the prevalence of respiratory pathogens involved in BRD in preweaned dairy calves, especially in small herds. OBJECTIVES To identify the main respiratory pathogens isolated from calves in Québec dairy herds with a high incide...