The Human Organ Transplant Act (HOTA) permitting transplantation of organs from brain-dead individuals was passed by the Indian parliament in 1994. In the 12 years since, only approximately 100 deceased-donor liver transplants (DDLT) have been performed in 18 centers countrywide. As per the Western liver transplant rates of 15-20 per million population (USA, UK), the number of patients requirin...

OBJECTIVE By audit from January to June 1989 to quantify, separately for hearts, kidneys, liver, lungs and corneas, the possible increases in transplantable organs from brain stem dead potential donors in intensive care units and to compare them with the increases achieved in October-November 1989, during intense, national publicity about transplantation. DESIGN Prospective audit of all death...

OBJECTIVES To review all published clinical studies of thyroid hormone administration to brain-dead potential organ donors. METHODS A search of PubMed using multiple search terms retrieved 401 publications including 35 original reports describing administration of thyroid hormone to brain-dead potential organ donors. Detailed review of the 35 original reports led to identification of two addi...

BACKGROUND As the demand for liver transplantation has become greater than the availability of donor livers, the criteria for donor selection or rejection are more important than ever before. In view of an increasing number of patients on the waiting list, some centres are expanding their donor pool by relaxing the criteria, such as by using organs from elderly (> 60 years) brainstem-dead donor...

inflammatory responses and innate immunologic reactions play an important role in the respiratory system. ex vivo lung perfusion (evlp) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. however, evlp’s effect on inflammatory and metabolic markers of human lung tissue is unknown. this study investigated how the performance of evlp on brain...

Hemodynamic instability after brain death is an universal clinical problem with effects on potential donor organs. Actual shortage of potential donor hearts continues to raise controversial discussion about adequate donor management with regard to graft quality. From the mid eighties numerous studies investigated the effects of brain death on the cardiocirculatory system and other organs. It co...