This article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates for surgery. Stereotactic radiosurgery (SRS) is recommended in patients with 1-3 BMF-NSCLC below 3-3.5 cm, with minor neurological symptoms, loc...

AIM To evaluate the efficacy of different radiotherapy treatment modalities in radioresistant brain metastasis. PATIENTS AND METHODS A retrospective analysis was conducted on 78 patients with brain metastases from melanoma, sarcoma, or renal cell carcinoma primary tumours who underwent radiosurgery (20 Gy) and/or hypofractionated stereotactic radiotherapy (6x4 Gy or 7x4 Gy) with or without wh...

Brain metastases develop in one-third of patients with non-small-cell lung cancer and are associated with a dismal prognosis, irrespective of surgery or chemo-radiotherapy. Pathological markers for predicting outcomes after surgical resection and radiotherapy responsiveness are still lacking. Caveolin 1 has been associated with chemo- and radioresistance in various tumors, including non-small-c...

Standard treatment for the majority of malignant brain tumours consists of surgery and radiotherapy. This treatment has late morbidity which is accentuated in the very young child. As part of a strategy to improve quality of life and overall survival of young children with brain tumours, members of the United Kingdom Children's Cancer Study Group (UKCCSG) have piloted an intensive chemotherapy ...

Abstract INTRODUCTION Brain metastases (BMs) are diagnosed in 10-30% of all cancer patients, and the incidence is expected to rise due advancements primary tumor management. Besides survival, impact treatment on quality life (QoL) course disease highly relevant for patients their caregivers. The Cohort patient-reported Outcomes, Imaging trial inclusion Metastatic BRAin (COIMBRA) study aims gath...

Radiotherapy is a standard recourse in the treatment of inoperable metastatic disease of bone and brain. The control of brain metastases with radiosurgery produces excellent results, and this strategy has progressively replaced initial surgery.[1] Radiotherapy of advanced primary lesions that are incompletely operable and lymph node metastases that are unresectableor recurrences that develop af...

Juvenile Nasopharyngeal carcinoma (NPC) is a rare head and neck cancer in Western Countries. Neck radiotherapy (RT) routine procedure for treating or preventing the nodal metastasis NPC patients. Ionizing radiation from RT has been associated with enhanced atherosclerotic process of large vessel arteries brain which results higher incidence cerebrovascular events.