introduction: a fixed hemodynamic response function (hrf) is commonly used for functional magnetic resonance imaging (fmri) analysis. however, hrf may vary from region to region and subject to subject. we investigated the effect of locally estimated hrf (in functionally homogenous parcels) on activation detection sensitivity in a heroin cue reactivity study. methods: we proposed a novel explora...

Quantitative criteria are proposed to identify genes (and sets of genes) whose expression marks a specific brain region (or a set of brain regions). Gene-expression energies, obtained for thousands of mouse genes by numerization of in situ hybridization images in the Allen Gene Expression Atlas, are used to test these methods in the mouse brain. Individual genes are ranked using integrals of th...