PURPOSE To evaluate and compare the effects of the following dyes on human pigmented epithelial cells: indocyanine green (ICG), infracyanine green (IfCG), trypan blue (TB), bromophenol blue (BrB), patent blue (PB), and Brilliant Blue G (BBG). METHODS ARPE-19 cells cultured in vitro were exposed to these dyes, and acute and chronic toxicity were evaluated. Cell viability was measured by colori...

Abstract In the field of high-end manufacturing, it is valuable to study few-shot health condition estimation. Although transfer learning and other methods have effectively improved ability learning, they still cannot solve lack prior knowledge. this paper, by combining data enhancement, knowledge reasoning, a generative knowledge-based model proposed achieve First, with effectiveness enhanceme...

Purpose: Approximately 30% higher grade premalignant oral intraepithelial neoplasia (OIN) lesions will progress to oral cancer. Although surgery is theOIN treatmentmainstay,manyOIN lesions recur, which is highly problematic for both surgeons andpatients. This clinical trial assessed the chemopreventive efficacy of a natural product-based bioadhesive gel on OIN lesions. Experimental Design: This...

Induction motors are indispensable, robust, and reliable machines for industry; however, as with any machine, they susceptible to diverse faults. Among the faults that a motor can suffer, broken rotor bars (BRBs) have become one of most studied ones because under this fault condition continue operating apparent normality, yet severity quickly increase and, consequently, generate whole collapse ...

The belief-rule-base (BRB) inference methodology using the evidential reasoning (ER) approach is widely used in different fields, such as fault diagnosis, system identification, and decision analysis. However, calculation characteristic of conventional rule activation weight makes have zero problem. difficulty constructing partial derivatives restricts optimization parameters gradient method. H...

Citation: van der Wijk A-E, Vogels IMC, van Noorden CJF, Klaassen I, Schlingemann RO. TNFa-induced disruption of the blood–retinal barrier in vitro is regulated by intracellular 3,5-cyclic adenosine monophosphate levels. Invest Ophthalmol Vis Sci. 2017;58:3496–3505. DOI:10.1167/ iovs.16-21091 PURPOSE. Proinflammatory cytokines such as tumor necrosis factor (TNFa) may have a causative role in bl...

Systemically administered pravastatin effectively treats diabetic retinopathy without central nervous system side effects. The efflux transport mechanism of pravastatin from the brain has already been clarified. In this study, the influx of pravastatin across the bloodretinal and blood-brain barriers (BRB and BBB) and the efflux of pravastatin from the retina were investigated using rats. Prava...

PURPOSE To determine whether sustained elevation of vascular endothelial growth factor (VEGF) in the vitreous cavity causes retinal hyperpermeability [blood-retinal barrier (BRB) breakdown] before the development of retinal neovascularization (NV) and to document the kinetics of the integrity of BRB breakdown versus time. METHODS Poly(L-lactide-co-glycolide)based devices loaded with VEGF were...

BACKGROUND Rye bread benefits glucose metabolism. It is unknown whether the same effect is achieved by rye bran-enriched wheat bread. We tested whether white wheat bread enriched with bioprocessed rye bran (BRB + WW) and sourdough wholegrain rye bread (WGR) have similar effects on glucose metabolism and plasma level of short chain fatty acids (SCFAs). METHODS Twenty-one (12 women) of 23 recru...