background: intraoperative radiation therapy (iort) technique is used to treat a surgically exposed tumor or tumor bed in the treatment of locally advanced intraabdominal, retroperitoneal, pelvic, thoracic, breast and soft tissue tumors. one way to perform iort is to use an existing linac and modify the treatment head using an applicator system. in this study the objectives were to design, and ...

Although there have been significant advances in the adjuvant therapy of colorectal cancer, results for patients have historically been poor when complete resection is unlikely or not possible. Similarly, locally recurrent colorectal cancer patients often experience significant tumor related morbidity and disease control and long term survival have historically been poor with standard therapies...

BACKGROUND To assess postoperative complications, clinical outcome and histological findings in patients undergoing intraoperative radiotherapy with low energy x-rays for early breast cancer. METHODS We retrospectively analysed data of 208 women who underwent intraoperative irradiation during breast conserving surgery (BCS) between 2002 and 2007. Demographic, clinical and surgical parameters ...

Breast conservation therapy (BCT) is the procedure of choice for the management of the early stage breast cancer. However, its utilization has not been maximized because of logistics issues associated with the protracted treatment involved with the radiation treatment. Accelerated Partial Breast Irradiation (APBI) is an approach that treats only the lumpectomy bed plus a 1-2 cm margin, rather t...

BACKGROUND The purpose of this article was to present the Beth Israel Medical Center experience using high-dose-rate intraoperative radiotherapy (HDR-IORT) in the management of recurrent head and neck cancer. METHODS We conducted a retrospective review of all patients with locally or regionally recurrent head and neck cancer who underwent HDR-IORT at our institution between 2001 and 2010. R...

Aim Patients with locally advanced and recurrent rectal cancer (LARC/LRRC) experience higher rates of local recurrence (LR) poorer overall survival than patients primary restricted to the mesorectum despite improved neoadjuvant treatment regimens radical surgical procedures. Intraoperative radiotherapy (IORT) has been suggested as an adjunctive tool in management these challenging cases. Howeve...

We investigated whether intraoperative radiotherapy (IORT) during curative surgery for esophageal carcinoma is useful or not. The cases of 117 patients diagnosed with thoracoabdominal esophageal carcinoma who underwent curative surgery between 1986 and 2007 were reviewed: 72 patients received IORT (IORT group) and 45 did not (non-IORT group). Upper abdominal lymphadenectomy was performed in 115...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...