نتایج جستجو برای: breast cancerous tissues
تعداد نتایج: 438636 فیلتر نتایج به سال:
Mammography is currently the most effective breast cancer screening technique. It has been shown by clinical studies that mammography has reduced the mortality by 30~50%. However, mammography is not a perfect technique in that about 30% of breast cancers are missed. A major limit to the sensitivity of conventional mammography is the superimposition of the breast tissue. A mammogram is a two-dim...
The mechanical properties of tissue change significantly during the progression from healthy to malignant. Quantifying the mechanical properties of breast tissue within the tumor microenvironment can help to delineate benign from cancerous stages. In this work, we study high-grade invasive ductal carcinoma in comparison with their matched tumor adjacent areas, which exhibit benign morphology. S...
ABSTRACTIntroduction: Cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. Comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. Methods: We constructed protein interaction networks of cancerous a...
To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 251I-IGFI binding was performed on frozen tissue sections and analysed using 'H Ultrofilm autoradiography coupled...
Computational and experimental evidence has revealed that cancerous cells express transcript variants that are abnormally spliced, suggesting that mRNAs are more frequently alternatively spliced in cancerous tissues than in normal ones. We show that cancerous tissues exhibit lower levels of alternative splicing than do normal tissues. Moreover, we found that the distribution of types of alterna...
Background: A powerful and improved technique, Proton Induced X-ray Emission (PIXE) has been performed-yielding the elemental composition of 17 samples of surgically excised malignant and normal tumors of breast tissue. The samples without any further process as thick targets were put on capton foil backing. There are no homogenizing processes. The PIXE spectra analysis was performed using he n...
Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. In controlled ADAR expression experiments, the editing frequency increased at all loci with ADAR expression levels according to the logistic model. Loci-specific "editabilities," i.e., p...
Background Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods In the current study, we evaluated the ex...
Aim: This study aims to investigate the possible effects of aqueous Echinacea (E. Purpurea, whole plant) extract on Adenosine deaminase (ADA) activity in cancerous and non-cancerous human gastric and colon tissues. Materials and Methods: Thirty three cancerous and 33 non-cancerous human gastric tissues, and 25 cancerous and non-cancerous human colon tissues removed by surgical operations were s...
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