BACKGROUND Dietary vitamin D has been associated with lower mammographic breast density, a strong biomarker for breast cancer risk. Blood 25-hydroxyvitamin D [25(OH)D] is an integrated measure of vitamin D status (from food, supplements, and sun exposure) and varies with season. Our objective was to assess seasonal variations of breast density and compare such variations, if any, with that of 2...

Mammographic breast density is a strong risk factor for breast cancer but whether breast density is a general marker of susceptibility or is specific to the location of the eventual cancer is unknown. A study of 372 incident breast cancer cases and 713 matched controls was conducted within the Mayo Clinic mammography screening practice. Mammograms on average 7 years before breast cancer were di...

Introduction Mammographic breast density is positively associated with risk of developing breast cancer for both preand postmenopausal women. Breast Imaging Reporting and Data System (BIRADS) or similar semiquantitative pattern analyses are inexpensive and suitable for large epidemiologic studies, but intrareader reliability in interpretation is suboptimal. Continuous, computerassisted measurem...

Factors associated with an increased risk of breast cancer include prior breast cancer, high circulating estrogens, and increased breast density. Adjuvant aromatase inhibitors are associated with a reduction in incidence of contralateral breast cancer. We conducted a prospective, single-arm, single-institution study to determine whether use of anastrozole is associated with changes in contralat...

UNLABELLED Theoretically, the degree of (18)F-FDG uptake in the glandular tissues of the normal breast can affect the detection of breast cancer. The aim of this prospective study was to investigate relationships among age, menopausal state, and breast density and determine whether they affect (18)F-FDG uptake in normal glandular breast tissue. METHODS Among 250 newly diagnosed breast cancer ...

BACKGROUND Adult mammographic percent density is one of the strongest known risk factors for breast cancer. In utero exposure to high levels of endogenous estrogens (or other pregnancy hormones) has been hypothesized to increase breast cancer risk in later life. We examined the hypothesis that those factors associated with higher levels of estrogen during pregnancy or shortly after birth are as...

Breast density is a recognized strong and independent risk factor for breast cancer. We propose the use of time-resolved transmittance spectroscopy to estimate breast tissue density and potentially provide even more direct information on breast cancer risk. Time-resolved optical mammography at seven wavelengths (635 to 1060 nm) is performed on 49 subjects. Average information on breast tissue o...

In the computer vision literature, there are two lines of scientific investigation into automated mammographic risk assessment. The first focuses on the correlation between mammographic risk and the parenchymal; and the second focuses on the correlation with the overall breast density. In addition, the sensitivity of mammography is significantly reduced by increased breast density which can mas...

BACKGROUND Mammographic breast density is a significant risk factor for breast cancer. Women with dense tissue accounting for more than 60-75% of the area of the breast have a 4- to 6-fold increase in their risk of breast cancer, compared to women with little or no breast density. A high circulating level of insulin-like growth factor-I (IGF-I) and low IGF binding protein 3 (IGFBP-3) level have...

The effects of menopausal vasomotor symptoms and changes in anthropometry on breast cancer etiology" (2015). opportunities that he has provided for me throughout this process. I am also indebted to our collaborators at the SWAN and BCSC facilities for their interest in and efforts towards this research. encouragement, and their belief in my success. I am more than grateful for everything you ha...