When the rZZ genes are first introduced into cells which had been previously infected by T4 phage deleted for these genes, the kinetics of synthesis of rZZA and rZZB RNA are rapid and identical. We show that this rapid synthesis depends on a functional motA gene for rZZB, but not for rZZA, RNA synthesis. By primer-extension mapping of T4 messenger RNA, we find three promoters close to the rZZA ...

INTRODUCTION Acute myopathy caused by oral corticosteroids is rare. We present a case of myopathy occurring after two doses of methylprednisolone. Typically, acute steroid myopathy occurs with therapy using intravenous corticosteroids at high doses. Acute myopathy developing very early in the course of treatment with oral corticosteroids has been reported only once in the literature. Corticoste...

This study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink, whether DNA could be obtained, and whether previously reported associations of statin myopathy with the SLCO1B1 c.521T>C and COQ2 rs4693075 polymorphisms could be replicated. Seventy-seven statin-induced myopathy patients (serum creatine p...

facioscapulohumeral muscular dystrophy (fshd) is a common inherited muscular dystrophy presented clinically with slowly progressive weakness and wasting of facial and limb muscles and rare bulbar muscle involvement. we present herein a 70-year-old man who was a known case of fshd with complaint of 15-day history of progressive difficulty in chewing and dysarthria and was found to have myastheni...

this syndrome is a shock-like hyper metabolic myopathy triggered in susceptible animals by stress. capture myopathy (c.m.) is a commonly occurring condition in mammals following trapping and transportation. in this case 12 to 24 hours after transportation of red deer (cevus elaphus) and wild goats (capra ibex) clinical signs such as: muscular tremor, ataxia, recumbency, hyperthermia, tachyca...

case presentation a 28-year old chinese female was treated with carbimazole (cmz) for graves’ disease with hyperthyroidism. two weeks later, she developed myalgia and proximal muscle weakness. investigations showed evidence of myopathy. cmz was stopped and rapid improvement of clinical condition and biochemical parameters ensued. conclusions rapid decrement of thyroid hormone level is recognize...

BACKGROUND Published studies regarding statin-associated myopathy may describe more dramatic patient presentations, potentially leading to inaccurate characterization of the condition. Furthermore, long-term outcomes and responses to statin rechallenge in patients with statin-associated myopathy are largely unknown. METHODS The University of Wisconsin Hospital and Clinics Medical Informatics ...