BACKGROUND Life-threatening ventricular tachyarrhythmias can occur in young patients without structural heart disease (idiopathic forms). In many patients, these are typically triggered by an increased sympathetic tone, eg, by physical or mental stress. In contrast, in Brugada syndrome, ventricular tachyarrhythmias more often occur during rest or sleep when the vagal tone is predominant. Furthe...

Recent studies have suggested an association between several channulopathy diseases. However, the mechanism remains unclear. The aim of this case was to demonstrate the relation between Brugada Syndrome (BrS) and Early Repolarization Syndrome (ERS). We presented herein a 46_year_old women with no familial history of sudden death. She was hospitalized for ventricular tachycardia with a lipothymi...

J wave syndrome has emerged from a benign electrocardiographic abnormality to a proarrythmic state and a significant cause of idiopathic ventricular fibrillation responsible for sudden cardiac death. Electrical genesis, genetics and ionic mechanisms of J wave syndromes are active areas of research. Typically two of these viz., Early repolarization syndrome (ER) and Brugada syndrome (BrS) are fa...

Schizophrenia is a mental disorder associated with a potential risk of sudden death. Furthermore, we have to take account of antipsychotic drugs as a major cause of sudden death in these patients (1). Some antipsychotic drugs (e.g., tricyclic antidepressants and thioridazine) have been reported to cause QT prolongation and/or torsade de pointes, which are induced by blocking of the rapidly acti...

Les maladies cardiovasculaires (MCV) contribuent de maniere significative a la morbidite et mortalite des patients atteints schizophrenie, le syndrome Brugada est une cause importante mais meconnue mort subite du cœur. Il plus frequemment observe dans schizophrenie que population generale [1] Le maladie arythmique hereditaire caracterisee par presence dun sus-decalage ST courbe (au moins 2 m...

The authors appreciate the interest in the case report we blished in Revista Española de Cardiologı́a concerning the servation of the Brugada electrocardiographic (ECG) pattern in patient with hyperkalemia. We likewise welcome the introducn of the concept of phenocopy, an expression with which our ding is compatible.We also consider it opportune to stress that th the latest consensus on ECG diag...

BACKGROUND Although Brugada syndrome revolves around reduced net depolarizing force, the electrophysiological mechanisms of its defining features (right precordial ST-segment elevation and ventricular tachyarrhythmias) remain unresolved. Two proposed mechanisms are (1) right ventricular (RV) conduction delay and (2) selective and significant RV subepicardial action potential shortening. Both me...

Brugada syndrome (BS) is an arrhythmogenic disease characterized by a typical electrocardiographic finding (type 1 Brugada electrocardiogram [ECG]) and an increased risk for sudden cardiac death (SCD) due to polymorphic ventricular tachycardia or ventricular fibrillation (VF). Risk stratification remains a challenge, especially in cases without documented cardiac arrest or VF. The role of progr...

Mutations in SCN5A lead to a broad spectrum of phenotypes, including the Long QT syndrome, Brugada syndrome, Idiopathic ventricular fibrillation (IVF), Sudden infant death syndrome (SIDS) (probably regarded as a form of LQT3), Sudden unexplained nocturnal death syndrome (SUNDS) and isolated progressive cardiac conduction defect (PCCD) (Lev-Lenegre disease). Brugada Syndrome (BS) is a form of id...

OBJECTIVES The study examined whether patients with Brugada syndrome are sensitive to vagal stimulation or ischemia. BACKGROUND Experimental studies have suggested that a prominent transient outward current (I(to))-mediated action potential notch and a subsequent loss of the action potential dome in the epicardium, but not in the endocardium, give rise to ST-segment elevation and subsequent v...