نتایج جستجو برای: buchwald
تعداد نتایج: 260 فیلتر نتایج به سال:
In this paper, a new analysis of the known topographic models Rossby waves for piecewise exponential topography profiles is performed. A mathematical method proposed that allows us to find analytically group velocity and variance. numerical comparison made relations presented in study Buchwald Adams dependencies obtained within framework analytical approach. Numerical comparative showed discrep...
Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination given opportunities to elegantly make pharmaceutical ingredients. Indeed, these at forefront of both stages drug development, medicinal chemistry, process chemistry. On one hand, chemists a resource derivatize core compound arrive scaffold rapidly. other ...
The direct arylation of N-(2-pyridyl) substituted anilines is described. Arylation takes place in ortho position to the amine functionality and is directed by the pyridine N-substituent. Remarkably, N-arylation was never observed as a competing process even though conditions also suitable for Buchwald-Hartwig reactions were applied. The scope of the reaction was investigated in terms of aryl do...
We report a procedure to linearly scale-up the synthesis of 2,8-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)dibenzothiophene-S,S-dioxide (compound 4) and 2,8-bis(10H-phenothiazin-10-yl)dibenzothiophene-S,S-dioxide (compound 5) using Buchwald-Hartwig cross-coupling reaction conditions. In addition, we demonstrate a scaled-up synthesis of all non-commercially available starting materials that are requ...
effects in normal human, Fanconi’s anaemia and xeroderma pigmentosum cells. Br J Cancer 67:1285, 1993 3. Hang B, Yeung AT, Lambert MW: A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A cells. Nuclic Acids Res 21:4187, 1993 4. Yamashita T, Kupfer G, Naf D, Suliman A, Joenje H, Asano S, D’Andrea AD:...
Novel synthetic methodologies allow increasingly efficient access to known organic materials, as well as the preparation of otherwise inaccessible species. Pd-catalyzed coupling of aromatic dihalides to ortho-diaminoarenes furnishes embedded stable N,N'-dihydropyrazines expediently and in often excellent yields. The embedded N,N'-dihydropyrazines can then be oxidized by MnO2 to give substituted...
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