1 Principal Investigator of Horticulture and Curator, USDA Naitonal Clonal Germplasm Repository for Asimina species, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601-2355. To whom reprint requests should be addressed. 2 Co-Investigator of Horticulture, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601-2355 Abstract The pawpaw [Asimina triloba (L.) ...

Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease. The arenavirus small RING finger protein called Z has been shown to be the main driving force of virus budding. The bu...

Asymmetric distribution of messenger RNAs is a widespread mechanism to localize synthesis of specific protein to distinct sites in the cell. Although not proven yet there is considerable evidence that mRNA localisation is an active process that depends on the activity of cytoskeletal motor proteins. To date, the only motor protein with a specific role in mRNA localisation is the budding yeast t...

Budding yeast are a fundamental organism at the center of systems biology research. Understanding the physiology and kinetics of their growth and division is fundamental to the design of models of gene regulation and the interpretation of experimental measurements. We have developed a Leslie model with structured volume and age classes to understand population growth and cell cycle synchrony in...

Osmotic deflation of vesicles enclosing two liquid phases can lead to bulging of one of the phases from the vesicle body. This budding process is preceded by a complete to partial wetting transition of one of the liquid phases on the membrane and depends on the membrane tensions and the tension of the interface between the enclosed liquid phases. These tensions dominate in different morphology ...

Background/Aim. The histological phenomenon of tumor budding is being recognized as an important determinant disease progression and poor prognosis in various types carcinoma. We aimed to evaluate the clinicopathological significance adenocarcinoma lung. Methods. study included 114 patients operatively treated for lung a one-year period. Microscopic analysis routine slides was performed establi...

1: Ampyra (fampridine SR) Lancet. 2009 Feb 28;373(9665):732-8. Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Goodman AD, Brown TR, Krupp LB, Schapiro RT, Schwid SR, Cohen R, Marinucci LN, Blight AR; Fampridine MS-F203 Investigators. Collaborators: Agius M, Arnason BG, Bethoux FA, Bever CT Jr, Bowen JD, Brown TR, Dietrich DW, Edwards K, Fr...

BACKGROUND Keratocysticodontogenic tumor (KCOT) is one of the most common odontogenic cysts and has a high recurrence rate after various treatment methods. Some studies have been conducted to identify the predictive factors of recurrence. In this study, the clinicopathological and immunohistochemical features of primary and recurrent KCOTs are analyzed, including immunohistochemically expressio...

Ebola virus budding is mediated by two proline-rich motifs, PPxY and PTAP, within the viral matrix protein VP40. We have previously shown that a Nedd4-like protein BUL1, but not Nedd4, positively regulates budding of type D retrovirus Mason-Pfizer monkey virus (J. Yasuda, E. Hunter, M. Nakao, and H. Shida, EMBO Rep. 3:636-640, 2002). Here, we report that the cellular E3 ubiquitin ligase Nedd4 r...

Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity esta...