We recently demonstrated that a variant allele of CYP3A5 (CYP3A5*3) confers low CYP3A5 expression as a result of improper mRNA splicing. In this study, we further evaluated the regulation of CYP3A5 in liver and jejunal mucosa from white donors. For all tissues, high levels of CYP3A5 protein were strongly concordant with the presence of a wild-type allele of the CYP3A5 gene (CYP3A5*1). CYP3A5 re...

results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...

Cyp3A5 activity varies within any given ethnic population, suggesting that genetic variation within the Cyp3A5 gene may be the most important contributor to interindividual and interracial differences in Cyp3A-dependent drug clearance and response. The full extent of Cyp3A5 polymorphism in a white and an indigenous African population was analyzed using DNA direct sequencing procedures. The pres...

Abstract Background To determine the clinical value of multigene polymorphisms, LDL-C and sdLDL-C on T2DM therapy. Methods In total, 352 patients before after treatment 48 healthy individuals were enrolled in this study. detected by Quantimetrix Lipoprint System. The 11 gene polymorphisms— HTR3B (rs2276307, A > G), APOE (rs7412, c.526C T), (rs429358, c.388 T C), CYP2C9*3 (rs1057910, c.1075A ...

We investigated the role of single nucleotide polymorphisms in genes encoding for drug-metabolizing enzymes in 209 newly diagnosed multiple myeloma patients included in a clinical trial comparing single with double intensive therapy. We observed no significant association between polymorphisms in CYP3A4, CYP3A5, MDR1, GSTM1 and GSTT1 and outcome either after treatment with induction chemotherap...

PURPOSE The purpose is to identify the demographic, physiologic, and inheritable factors that influence CYP3A activity in cancer patients. EXPERIMENTAL DESIGN A total of 134 patients (62 females; age range, 26 to 83 years) underwent the erythromycin breath test as a phenotyping probe of CYP3A. Genomic DNA was screened for six variants of suspected functional relevance in CYP3A4 (CYP3A4*1B, CY...

background: the association between interleukin‑6 (il‑6) (‑174g/c) gene polymorphisms and level of tissue breakdown and periodontal disease progression is unknown. the present study investigated quantitative parameters of interdental papilla in chronic periodontitis (cp) patients with il‑6 (‑174g/c) gene polymorphisms. materials and methods: sixty gingival samples were studied. after determinat...

background: ovarian cancer is a relatively common cancer among postmenopausal women. nowadays, there is controversy about immunotherapy of ovarian cancer patients with interleukins such as interferon to reach better out come in prognosis of patients under chemotherapy. ctla-4 is a gene, which has an important role in homeostasis and regulation of immune response. inhibitory nature of ctla-4 is ...

Growth hormone gene plays a critical role in regulating growth and metabolism which leads to potential correlations between the polymorphisms of this gene and economic trait. A 776 bp fragment within the intron 1 region of the growth hormone gene from 346 individuals of an F2 population of Japanese quail was amplified. The polymerase chain reaction (PCR) product was digested using MspI restrict...