Abstract 70-weeks-old female C57BL6 senescence marker protein 30 knock out mice exhibited anorexia, lethargy and enlarged abdomen because of an intraperitoneal mass. On necropsy, the mouse revealed a large brown-whitish mass located on mesentery. The also systemic metastasis spread over in various organs. microscopic findings, neoplastic masses were mainly composed round cells characterized by ...

The importance of B cells in host resistance to, and recovery from, Cryptosporidium parvum infection was examined in gene-targeted B cell-deficient (muMT-/-) mice. Neonatal muMT-/- mice infected with C. parvum at 5 days of age completely cleared the infection by day 20 PI. The kinetics of infection and clearance were similar to those seen with age-matched C57BL/6 control mice. Furthermore, B ce...

It has been proposed that diet-induced obesity at thermoneutrality (TN; 29°C) is reduced by a UCP1-dependent thermogenesis; however, it has not been shown how UCP1-dependent thermogenesis can be activated in the absence of sympathetic activity. A recent study provides such a mechanism by showing that dietary bile acids (BAs) suppress obesity in mice fed a high-fat diet (HFD) by a mechanism depe...

Hepatic inflammation is a key pathological feature of Nonalcoholic Steatohepatitis (NASH). Natural Killer T-cells (NKT) and CD8+ T-cells are known to play an important role in obesity related adipose tissue inflammation. We hypothesized that these same inflammatory phenotypes would be present in progressive NASH. We used a previously established high fat high carbohydrate (HFHC) murine obesogen...

Abstract Background Obesity‐related asthma, a specific type of tends to have more severe symptoms and frequent exacerbations, it is insensitive standard medications. Plumbagin (PLB) has many positive effects on human health. However, remains unclear whether PLB protects against obesity‐related asthma. The study investigated the effect Methods Four‐week‐old male C57BL6/J mice were fed either sta...

Abstract Background Like in other chronic pathologies, evidence has shown disruption of host immune-microbial interactions and intestinal dysbiosis the pathogenesis Inflammatory Bowel Diseases (IBD), also characterized by inflammation increased permeability. Faecal microRNAs (miRNAs) have recently emerged as potential inter-kingdom mediators between its microbiota, but influence interaction on ...