نتایج جستجو برای: cad pathogenesis

تعداد نتایج: 143211  

Journal: :European review for medical and pharmacological sciences 2015
R Gong M-H Chen L-S Peng S-L Wei

OBJECTIVE Coronary artery disease (CAD) remains one of the major causes of death worldwide. Despite considerable advances in the prevention and treatment of CAD, its complications, morbidity and mortality still remain very high, and vary widely across different ethnic groups. MATERIALS AND METHODS To detect genes involved in the development of CAD, we collected gene expression studies in the ...

Journal: :The Indian journal of medical research 2007
Surjit Singh S Venketesh J S Verma Minni Verma C O Lellamma R C Goel

BACKGROUND & OBJECTIVE Paraoxonase (PON1), an arylesterase is associated with high density lipoprotein cholesterol (HDL-C). PON1 prevents low density lipo-protein cholesterol (LDL-C) from peroxidation and can also hydrolyze lipid peroxides, thereby providing protection against atherosclerosis and coronary artery disease (CAD). The incidence of CAD is known to be high in north western Indian Pun...

Journal: :Circulation journal : official journal of the Japanese Circulation Society 2016
Brittany A Potz Ashraf A Sabe M Ruhul Abid Frank W Sellke

Despite many advances in percutaneous and surgical interventions in the treatment of coronary artery disease (CAD), up to one-third of patients are still either not candidates or receive suboptimal revascularization. Calpains are a class of calcium-activated non-lysosomal cysteine proteases that serve as a proteolytic unit for cellular homeostasis. Uncontrolled activation of calpain has been fo...

Journal: :Hypertension 2017
Andrew O Kadlec Dawid S Chabowski Karima Ait-Aissa Joseph C Hockenberry Mary F Otterson Matthew J Durand Julie K Freed Andreas M Beyer David D Gutterman

Blood flow through healthy human vessels releases NO to produce vasodilation, whereas in patients with coronary artery disease (CAD), the mediator of dilation transitions to mitochondria-derived hydrogen peroxide (mtH2O2). Excessive mtH2O2 production contributes to a proatherosclerotic vascular milieu. Loss of PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α) is implicated in...

Journal: :European Heart Journal 2022

Abstract Background Microbiome has been linked to the pathogenesis of coronary artery disease (CAD) but data providing direct evidence for an association short-chain fatty acids (SCFA) like propionate with CAD are lacking. Purpose To study in blood samples presence Methods This was a cross-sectional enrolling patients admitted invasive angiography university hospital Germany. Patients were pros...

Journal: :European Heart Journal 2022

Abstract Background High-density lipoprotein (HDL) function rather than concentration plays an important role in the pathogenesis of cardiovascular diseases associated with oxidative stress and inflammation such as coronary artery disease (CAD). In last years, has been identified to have a pivotal acute syndrome (ACS). Purpose The aim present study is determine whether reduced antioxidant HDL A...

2016
Ismail Ungan Fatma Nihan Turhan Caglar İsmail Biyik Serkan Ciftci Alpaslan Sahin Ibrahim Faruk Akturk

INTRODUCTION Inflammation plays a key role in atherosclerosis, and discovering new biomarkers of inflammation is becoming important in order to uncover the pathogenesis of atherosclerotic coronary artery disease (CAD). Recent studies have focused on polymorphonuclear neutrophils. It has been suggested that human neutrophil peptide 1-3 (HNP1-3) is proatherogenic. In this study, we aimed to inves...

2015
Min-Yi Lee Chun-Hao Huang Chao-Jen Kuo Chen-Lung Steve Lin Wen-Ter Lai Shyh-Horng Chiou

Inflammation plays a key role in coronary artery disease (CAD) and other manifestations of atherosclerosis. Recently, urinary proteins were found to be useful markers for reflecting inflammation status of different organs. To identify potential biomarker for diagnosis of CAD, we performed one-dimensional SDS-gel electrophoresis followed by liquid chromatography coupled with tandem mass spectrom...

Journal: :International journal of clinical and experimental medicine 2015
Dilare Adi Xiang Xie Fen Liu Yi-Tong Ma Mayila Abudoukelimu Yun Wu Yong An Yi-Ning Yang Xiao-Mei Li Zhen-Yan Fu Yong-Tao Wang Bang-Dang Chen

OBJECTIVE Proprotein convertase subtilisin-like kexin type 9 (PCSK9) gene E670G Polymorphism has been reported to be associated with coronary artery disease (CAD) and risk factors. However, the results remain controversial. We sought to perform a meta-analysis to investigate the relationships between genetic polymorphisms of E670G in PCSK9 gene and the risk of CAD. METHODS Literature searches...

Journal: :Circulation 1973
P P Steele H S Weily H Davies E Genton

Platelets have been implicated and abnormal platelet function proposed in the pathogenesis of coronary artery disease (CAD). This investigation examines platelet function in men with stable, arteriographically defined CAD and correlates results with lipid pattern, history of angina or 'myocardial infarction and smoking habits. Platelet survival (51Chromium method), adhesiveness, and aggregation...

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