Đặt vấn đề: Nhiễm vi khuẩn Helicobacter pylori (H. pylori) có liên quan đến một số bệnh dạ dày. Gen cag-PAI được xếp là trong yếu tố độc lực trọng của H. pylori. Các nghiên cứu cho biết tần suất chiếm 60-70% tổng các chủng phương Tây và 100% Đông Á. Tại Việt Nam, gen chưa nhiều. Mục tiêu: Nghiên tìm hiểu vai trò lý dày mối với ung thư tại Nam. Đối tượng & pháp: cắt ngang trên 623 nhân nhiễm...

The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has been investigated using enzymatic analysis, direct binding studies, site-directed mutagenesis, and molecular modeling studies. Previously PAI-039 has been shown to exhibit in vivo activity in various animal models, but the mechanism of inhibition is unknown. PAI-039 boun...

BACKGROUND To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men. METHODOLOGY/PRINCIPAL FINDINGS Whole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalci...

BACKGROUND The gold standard test for the diagnosis of coronary artery disease (CAD) is conventional coronary angiography (C-CAG). Lately, multislice computed tomographic coronary angiography (MSCT-CAG) demonstrated a high sensitivity and a negative predictive value for a CAD primary diagnosis when compared with C-CAG. The aim of our study is to prospectively assess the safety of ruling out CAD...

Summary Gastric cancer is the fifth most common and third leading cause of death worldwide. Patients with chronic atrophic gastritis (CAG) intestinal metaplasia (IM) are at increased risk developing gastric (GC). It for CAG to precede IM, but etiology two conditions not always same. Different scoring systems used assess HAG, MI, GC risk, making it difficult interpret results from investigations...

Abstract Background Contemporary real-world data on conservatively managed patients with acute coronary syndrome (ACS) is scarce. Objective To evaluate conservative management compared revascularization therapy in ACS patients, focused ischemic and bleeding outcomes at one year follow-up, to provide insight physician's rationale of choice for management. Methods From January 2015 2020, were enr...

huntington’s disease (hd) is an inherited neurodegenerative disorder characterized by chorea and progressive dementia. the mutation causing the disease has been identified as an unstable expansion of a tri-nucleotide (cag) n at the 5 end of the it 15 gene on chromosome 4. we analyzed the distribution of cag repeats in 66 iranian patients belonging to 66 unrelated families. we found one expanded...