Abstract Embryonal central nervous system tumors require genetic and epigenetic molecular analyses for further classification owing to the pathological, clinical, heterogeneity among these tumors. Here, we report a case of an infantile pineal tumor showing pathological features CNS ganglioneuroblastoma; however, specimen also contained SMARCA4 mutations methylation signature that is close atypi...

s Background Intracranial calcifications are veritable radiological pointer to pathologies. Therefore there is need to differentiate physiological and pathological calcifications. Objective Todetemine the incidence of physiological intracranial calcifications and relationship to age and sex. Materials And Methods A cross sectional descriptive study of the computed tomograms (CT) of the brain wa...

Basic calcium phosphate (BCP) crystal deposition underlies the development of arterial calcification. Inflammatory macrophages colocalize with BCP deposits in developing atherosclerotic lesions and in vitro can promote calcification through the release of TNF alpha. Here we have investigated whether BCP crystals can elicit a proinflammatory response from monocyte-macrophages. BCP microcrystals ...

conclusions there is a significant correlation between tympanosclerosis and h. pylori (p = 0.002). this correlation can single out h. pylori as a pathological factor in the development of tympanosclerosis; however, further studies are needed to prove this correlation. results from a total of 19 patients with tympanosclerosis , 16 cases (84.2%) were h. pylori positive, while in the control group...

BACKGROUND Klotho-knockout mice (klotho(-/-)) have increased renal expression of sodium/phosphate cotransporters (NaPi2a), associated with severe hyperphosphatemia. Such serum biochemical changes in klotho(-/-) mice lead to extensive soft-tissue anomalies and vascular calcification. To determine the significance of increased renal expression of the NaPi2a protein and concomitant hyperphosphatem...

High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis with normal tooth eruption and bone elongation and inhibit the development and activity of endosteal, but not periosteal, osteoclasts. We demonstrate that both intravenous injection of recombinant OPG protein and transgenic overexpression of OPG in OPG(-/-) mice effectively rescue the osteoporotic bone phen...

BACKGROUND Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the pres...

OBJECTIVE Aortic valve disease, including calcification, affects >2% of the human population and is caused by complex interactions between multiple risk factors, including genetic mutations, the environment, and biomechanics. At present, there are no effective treatments other than surgery, and this is because of the limited understanding of the mechanisms that underlie the condition. Previous ...

AIMS Aortic valve stenosis (AS) is the most common valvulopathy and is characterized by inflammation, extracellular matrix (ECM) remodelling and calcification, causing a narrowing of the valve and the consequential obstruction of the cardiac outflow. Although intraleaflet haemorrhage is associated with AS progression, the mechanisms involved are not known. The aims of this study were to identif...

BACKGROUND Aortic valve calcification (AVC) secondary to renal failure (RF) is an inflammation-regulated process, but its pathogenesis remains unknown. We sought to assess the cellular processes that are involved in the early phases of aortic valve disease using a unique animal model of RF-associated AVC. METHODS Aortic valves were obtained from rats that were fed a uremia-inducing diet exclu...