نتایج جستجو برای: calcineurin inhibitors
تعداد نتایج: 193080 فیلتر نتایج به سال:
BACKGROUND Extracellular signal-regulated kinases (ERKs) and calcineurin have been reported to play important roles in the development of cardiac hypertrophy. We examined here the relation between calcineurin and ERKs in cardiomyocytes. METHODS AND RESULTS Isoproterenol activated ERKs in cultured cardiomyocytes of neonatal rats, and the activation was abolished by chelation of extracellular C...
The pathogenic yeast Cryptococcus gattii, which is causing an outbreak in the Pacific Northwest region of North America, causes life-threatening pulmonary infections and meningoencephalitis in healthy individuals, unlike Cryptococcus neoformans, which commonly infects immunocompromised patients. In addition to a greater predilection for C. gattii to infect healthy hosts, the C. gattii genome se...
version from calcineurin inhibitors to sirolimus versus continued use of calcineurin inhibitors in renal allograft recipients. ATC Seattle 2005 28. Saurina A, Campistol JM, Piera C et al. Conversion form calcineurin inhibitors to sirolimus in chronic allograft dysfunction: changes in glomerular hemodynamics and proteinuria. Nephrol Dial Transpl; in press 29. Fervenza FC, Fitzpatrick PM, Mertz J...
Management of steroid-resistant minimal change disease remains elusive with international guidelines suggesting high-dose corticosteroids and/or Calcineurin inhibitors for months similar to those refractory idiopathic FSGS. Unfortunately, such approach, the overall remission rates were 47% - 66%. Moreover, complete 32% and partial ones 19% 29%. Those limited options treatment their poor outcome...
Calcineurin inhibitors such as cyclosporine A and FK506 are effective immunosuppressants but produce severe side effects. Rational modification of a previously reported peptide inhibitor, GPHPVIVITGPHEE (KD ∼ 500 nM), by replacing the two valine residues with tert-leucine and the C-terminal proline with a cis-proline analogue, gave an improved inhibitor ZIZIT-cisPro, which binds to calcineurin ...
BACKGROUND Physicians traditionally treat ulcerative colitis (UC) using a step-up approach. Given the paucity of data, we aimed to assess the cumulative probability of UC-related need for step-up therapy and to identify escalation-associated risk factors. METHODS Patients with UC enrolled into the Swiss IBD Cohort Study were analyzed. The following steps from the bottom to the top of the ther...
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