Using a sensitive radioimmunoassay, we detected human immunoreactive calcitonin in cell extracts and in cell-exposed media of the HL60 cell line derived originally from a patient with acute promyelocytic leukemia. The cell extract was chromatographed on a reverse-phase high-pressure liquid chromatography system. Radioimmunoassay of the fractions showed that the immunoreactive calcitonin was het...

Although it is well established that parathyroid hormone and phosphate are important regulators of 1,25-dihydroxyvitamin D [1,25(OH)2D] production, it remains unclear whether calcitonin affects vitamin D metabolism in vivo. Experiments were performed in the rat to determine the effect of chronic calcitonin infusion (0.2 U X h-1) on plasma levels of vitamin D metabolites and on calcium metabolis...

The literature about the effects of systemically administered calcitonin on fracture healing and in the prevention of disuse osteoporosis after fracture are reviewed in this study. Fracture healing is a biological process of great importance for the survival of the injured animal. Endochondral ossification is augmented in the fracture site followed by fast remodeling of the produced woven bone....

We used the calcitonin/calcitonin gene-related peptide (CGRP)-alpha gene knockout model (Ct/Cgrp null) to determine whether calcitonin and CGRPalpha are required for normal fetal mineral homeostasis and placental calcium transfer. Heterozygous (Ct/Cgrp(+/-)) and Ct/Cgrp null females were mated to Ct/Cgrp(+/-) males. One or two days before term, blood was collected from mothers and fetuses and a...

root resorption (rr) is defined as the loss of dental hard tissues because of clastic activity inside or outside of tooth the root. in the permanent dentition, rr is a pathologic event; if untreated, it might result in the premature loss of the affected tooth. several hypotheses have been suggested as the mechanisms of root resorption such as absence of the remnants of hertwig's epithelial root...

We examined the incidence of vertebral and non-vertebral fractures in published randomised clinical trials using calcitonin by parenteral injection or intranasal spray. Trials were reviewed that compared calcitonin with placebo, no therapy, or calcium with or without vitamin D, and that mentioned fracture as an outcome. Studies that compared the effect of calcitonin with other active treatments...

BACKGROUND/AIMS Mesenchymal stem cells from human amniotic fluid (huAFMSCs) can differentiate into multiple lineages and are not tumorigenic after transplantation, making them good candidates for therapeutic purposes. The aim was to determine the effects of calcitonin on these huAFMSCs during osteogenic differentiation, in terms of the physiological role of calcitonin in bone homeostasis. MET...

In order to study the effect of calcitonin on the bone collagen metabolism in osteolathyrism, male Wistar rats were placed on 0.1% aminoacetonitrile diet for 9 days. Porcine calcitonin dissolved in gelatin was concurrently administered in a dose of 0.1 MRC U/100g body weight for 8 days and on the 9th day 0.75 MRC U/100g body weight was given 3, 2 and 1hr respectively before sacrifice. Both bone...

Purpose. Measurement of serum calcitonin is important in the followup of patients with medullary thyroid carcinoma (MTC) and reliably reflects the presence of the disease. This is the largest study so far in bibliography investigating the diagnostic accuracy of combined [(18)F]FDG-PET/CT in patients with MTC and elevated calcitonin levels. Methods. Between February 2007 and February 2011, 59 [(...

Experiments examined activational roles of gonadal steroids on the sexually dimorphic, calcitonin gene-related peptide-expressing neurons of the rat preoptic area. Gonadectomy of male rats followed by treatment with testosterone, dihydrotestosterone, or estrogen demonstrated that the tonic suppressive influence of testosterone on cellular levels of calcitonin gene-related peptide mRNA expressio...