Background: Obesity is associated with impaired vascular function. In the cardiovascular system, protease-activated receptor 2 (PAR2) exerts multiple functions such as the control of the vascular tone. In pathological conditions, PAR2 is related to vascular inflammation. However, little is known about the impact of obesity on PAR2 in the vasculature. Therefore, we explored the role of PAR2 as a...

Skin cancer is the most common cancer in the USA. Non-melanoma skin cancers, which include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), comprise the majority. BCC and SCC are commonly treated with surgical excision, curettage, cryotherapy and radiation. Actinic keratoses (AK) are considered precursors of SCC and are commonly treated with 5-fluorouracil, imiquimod, diclofenac, l...

BACKGROUND Since the publication of a major international case-control study on the risk of agranulocytosis associated with the use of medicines in the 1980s, many new drugs have been introduced in therapeutics. METHODS Seventeen units of hematology contribute to the case-control surveillance of agranulocytosis and aplastic anemia in Barcelona, Spain. After a follow-up of 78.73 million person...

the comparison of total and ionised serum calcium level in preeclamptic pregnant women and the women with normal pregnancy   z. salari md1*, n. eftekhari md2     1- assistan professor, dept of gynecology, university of medical sciences, kerman, iran 2- associated professor, dept of gynecology, university of medical sciences, kerman, iran     background: preeclampsia remains one of the important...