Luminal free fatty acids and bile acids may damage the colonic epithelium and stimulate proliferation, which may increase the risk of colon cancer. It has been suggested that only soluble calcium ions (Ca2+) precipitate fatty acids and bile acids, thus reducing their lytic activity. Consequently, precipitation of luminal Ca2+ by dietary phosphate should inhibit these effects. To evaluate the pr...

General comments in relation to bone mineral metabolism: • In Stage 5 kidney disease, serum phosphate, serum calcium, calcium x phosphate product and parathyroid hormone (PTH) level need to be considered simultaneously when assessing the bone mineral status of a patient: a combination of high calcium, high phosphate and low PTH level being associated with the worst outcome. (Level III evidence ...

The inhibition of calcium phosphate precipitation by homoand copolymers containing different functional groups has been examined in aqueous solution. It has been found that polymer performance as calcium phosphate inhibitor depends upon polymer architecture. The influence of iron oxide (Fe2O3, rust) on the performance of calcium phosphate inhibitors has also been investigated. Results show that...

Because of an elevated serum phosphate level, patients who suffer from chronic kidney failure frequently tend to have cardiovascular calcification and are therefore exposed to a higher probability of a fatal event. Phosphate binders are able to reduce these negative effects. Currently, there are primarily two groups of phosphate binders (calcium-containing and calcium-free phosphate binders) wh...

Recently we have shown that supplemental dietary calcium precipitates luminal cytolytic surfactants and thus inhibits colonic epithelial proliferation, which may decrease the risk of colon cancer. In Western diets, milk products are quantitatively the most important source of dietary calcium. However, they also contain large amounts of phosphate, which has been hypothesized to inhibit the antip...

BACKGROUND Calcium nephrolithiasis is a multifactorial disease with a polygenic milieu. Association studies identified genetic polymorphisms potentially implicated in the pathogenesis of calcium nephrolithiasis. The present article reviews the mechanisms of calcium stone formation and the potential contribution of gene polymorphisms to lithogenic mechanisms. SUMMARY Endoscopy observations sug...

Tumoral calcinosis and calciphylaxis are uncommon complications of haemodialysis therapy and are associated with poor phosphate and calcium control. The use of calcium containing phosphate-binding agents in conjunction with high calcium dialysates may exacerbate these conditions by inducing a positive calcium balance. Despite their common aetiology, the two disorders are seldom reported to occu...

Calcium phosphate nanoparticle based films show shape dependent increase of hMSC osteogenic marker expression and morphology.

Due to the similar chemical properties to the inorganic component in calcified tissues, synthetic calcium phosphate has been considered as ideal biomaterials with excellent biocompatibility. Nanostructured calcium phosphate materials play an important role in the formation of hard tissues in nature. It is reported that calcium phosphates materials in nano-size can mimic the dimensions of consti...

BACKGROUND Smaller nanoparticles facilitate the delivery of DNA into cells through endocytosis and improve transfection efficiency. The aim of this study was to determine whether protamine sulfate-coated calcium phosphate (PS-CaP) could stabilize particle size and enhance transfection efficiency. METHODS pEGFP-C1 green fluorescence protein was employed as an indicator of transfection efficien...