نتایج جستجو برای: calr
تعداد نتایج: 723 فیلتر نتایج به سال:
The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin (CALR), and myeloproliferative leukemia virus (MPL), abnormally activate the cytokine receptor/JAK2 pathway and their downstream effectors, more particularly the STATs. The most frequent mutation, JAK2V617F, activates the 3 ...
Summary Calreticulin (CALR) is a highly conserved multi-function protein that primarily localizes within the lumen of endoplasmic reticulum (ER). It participates in various processes cells, including glycoprotein chaperoning, regulation Ca 2+ homeostasis, antigen processing and presentation for adaptive immune response, cell adhesion/migration, proliferation, immunogenic death, gene expression ...
Myeloproliferative neoplasms (MPNs) are characterized by a pathologic expansion of myeloid lineages. Mutations in JAK2, CALR and MPL genes known to be three prominent MPN disease drivers. Mutant (mutCALR) is an oncoprotein that interacts with activates the thrombopoietin receptor (MPL) represents attractive target for targeted therapy mutated MPN. We generated transgenic murine model conditiona...
This paper is devoted to the study of cloaking via anomalous localized resonance (CALR) in the twoand three-dimensional quasistatic regimes. CALR associated with negative index materials was discovered by Milton and Nicorovici [21] for constant plasmonic structures in the two-dimensional quasistatic regime. Two key features of this phenomenon are the localized resonance, i.e., the fields blow u...
ترومبوسیتمی اولیه، مایلوفیبروزو پلی سایتمی ورا از خانواده نئوپلاسم های مایلوپرولیفراتیو بوده که از نظر کروموزوم فیلادلفیا منفی هستند. آزمایش کروموزوم فیلادلفیا با 100% اختصاصیت برای تشخیص لوسمی مزمن مایلوسیتیک راه را برای تشخیص لوسمی هموار کرده است. جهش های ژن jak2 در بیش از 95 درصد موارد پلی سایتمی ورا و حدود 50 درصد موارد مایلوفیبروز و ترومبوسیتمی اولیه مشاهده می گردد. گمان می رود که با پیدای...
The Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic diseases characterized by bone marrow proliferation of one or more of the myeloid cell lineages with no marked alterations in cellular maturation. MPN classically comprise the clinically and pathologically related polycythemia vera (PV), essential thromobocythemia (ET), and primary myelof...
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