In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains ...

The approach Clark labels "action-oriented predictive processing" treats all cognition as part of a system of on-line control. This ignores other important aspects of animal, human, and robot intelligence. He contrasts it with an alleged "mainstream" approach that also ignores the depth and variety of AI/Robotic research. I don't think the theory presented is worth taking seriously as a complet...

Symbiotic Miras give a nice practical demonstration of the formation of bipolar and highly aspherical nebulae as a consequence of interaction in detached binaries. We believe that these binary systems are among the most promising candidates for the progenitors of bipolar planetary nebulae. We present a list of the optically extended nebulae known to date around symbiotic Miras, and illustrate t...

A realist view of numbers often rests on the following thesis: statements like ‘The number of moons of Jupiter is four’ are identity statements in which the copula is flanked by singular terms whose semantic function consists in referring to a number (henceforth: Identity). On the basis of Identity the realists argue that the assertive use of such statements commits us to numbers. Recently, som...

BACKGROUND Suicide continues to be a leading cause of death globally. Friends and family are considered best positioned to provide initial assistance if someone is suicidal. Expert consensus guidelines on how to do this were published in 2008. Re-developing these guidelines is necessary to ensure they contain the most current recommended helping actions and remain consistent with the suicide pr...

In this paper, we analyse Java source code of embedded database applications by means of static code analysis. If the underlying database schema is changed due to refactoring or database tuning, then the SQL statements in the embedding Java program need to be adapted correspondingly. This should be done mostly automatically, since changing software manually is error–prone and time consuming. Fo...

and reasoning skills, and for professional identity formation and professional behaviour. Clinical diagnostic decisionmaking is primarily based on pattern recognition [6], which requires extensive experience with patients. The more the better. Many valid illness scripts in the long-term memory of clinicians are needed to adequately recognize patterns or stimulate analytic reasoning. It has long...

In reading tasks, words that convey a false statement elicit an enhanced N400 brainwave response, relative to words that convey a true statement. N400 amplitude reductions are generally linked to the online expectancy of upcoming words in discourse. White lies, contrary to false statements, may not be unexpected in social scenarios. We used the event-related potential (ERP) technique to determi...