= Abstract =In Korea, leading causes of death have dramatically changed from infectious diseases to chronic degenerative illnesses, including malignant neoplasms since 1960. However, little is known about the long-term trends of female malignancies in Korea. This study was conducted to find epidemiological evidence of changes in mortality and morbidity of uterine cervix, female breast, and ovar...

Of all the rights of women, to become a mother is greatest. Nature has endowed every woman with the power of procreation. But how, at times, she has to suffer series of obstacles to achieve this goal, challenging her own life. Carcinoma Cervix is the most challenging cancer during pregnancy as the pregnant uterus itself is affected. It’s a challenge for all the mother, the family and the treati...

OBJECTIVE To investigate the 5-year relative survival rates in gynecological cancers diagnosed and treated in Turkey by year 2009 and to compare the results with developed countries. METHODS Data of patients diagnosed for ovarian, corpus uteri or cervix uteri cancer at year 2009 are collected from 9 national cancer registry centers. Date of deaths are retracted from governmental Identity Info...

Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that VHR is upregulated in several cervix cancer cell lines as well as in carcinomas of the uterine cervix. Here we report the development of multidentate small-molecule inhibitors of VHR that inhibit its enzym...

Background An immunosuppressive state had been identified in women with persistent infection by the human papillomavirus (HPV), characterized by high levels of interleukin (IL)10 at cervix level [1]. The present study analyzed the association of SNPs in the regulatory region of the IL10 gene with the risk of developing squamous intraepithelial lesions of the cervix (SIL) and cervical cancer (CC...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

In 2020, cancers of the breast, lip and oral cavity cervix were three most common in India.(1) The national programme for prevention control cancer, diabetes, cardiovascular diseases stroke (NPCDCS) recommends a population-based screening identifying pre-cancerous lesions early detection these by front line health workers.(2) Data about cancer has been included latest National Family Health Sur...

INTRODUCTION High-risk human papilloma viruses play a main role in the development of cervical dysplasias and carcinomas. p16INK4a can be considered as a surrogate marker of active high-risk human papillomaviruses infection in dysplastic and neoplastic cells of the cervix. This study was aimed at determining the presence and level of pl6INK4a expression in inflammatory, preneoplastic and neopla...

Cancer is one of the most prevalent causes mortality worldwide. In cervix, it confirmed to be caused by different high-risk human papillomavirus (HPV) types. Although many studies have already been conducted worldwide on epidemiology HPV infection and their oncogenic properties, limited data are available prevalence, incidence its impacts in Egypt.