نتایج جستجو برای: capping

تعداد نتایج: 6162  

2012
Eric Alix Laurent Chesnel Brad J. Bowzard Aimee M. Tucker Anna Delprato Jacqueline Cherfils David O. Wood Richard A. Kahn Craig R. Roy

The Legionella pneumophila effector protein RalF functions as a guanine nucleotide exchange factor (GEF) that activates the host small GTPase protein ADP-ribosylation factor (Arf), and recruits this host protein to the vacuoles in which this pathogen resides. GEF activity is conferred by the Sec7 domain located in the N-terminal region of RalF. Structural studies indicate that the C-terminal re...

2011
Stephen Gregory Addinall Eva-Maria Holstein Conor Lawless Min Yu Kaye Chapman A. Peter Banks Hien-Ping Ngo Laura Maringele Morgan Taschuk Alexander Young Adam Ciesiolka Allyson Lurena Lister Anil Wipat Darren James Wilkinson David Lydall

To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1) or containing a null mutation in the DNA damage response and telomere capping gene YKU70 (yku70Δ). We performed Quantitative Fitness Analysis (QFA) on thousands of yeast strains conta...

Journal: :Current Biology 2003
Martin A. Wear Atsuko Yamashita Kyoungtae Kim Yuichiro Maéda John A. Cooper

Cytoskeletal filaments are often capped at one end, regulating assembly and cellular location. The actin filament is a right-handed, two-strand long-pitch helix. The ends of the two protofilaments are staggered in relation to each other, suggesting that capping could result from one protein binding simultaneously to the ends of both protofilaments. Capping protein (CP), a ubiquitous alpha/beta ...

Journal: :Genetics 2008
Yikang S Rong

The conserved histone variant H2A.Z fulfills many functions by being an integral part of the nucleosomes placed at specific regions of the genome. Telomeres cap natural ends of chromosomes to prevent their recognition as double-strand breaks. At yeast telomeres, H2A.Z prevents the spreading of silent chromatin into proximal euchromatin. A role for H2A.Z in capping, however, has not been reporte...

Journal: :Nucleic acids research 1999
C R Rodriguez T Takagi E J Cho S Buratowski

The Saccharomyces cerevisiae mRNA capping enzyme consists of two subunits: the RNA 5'-triphosphatase (Cet1) and the mRNA guanylyltransferase (Ceg1). Using computer homology searching, a S. cerevisiae gene was identified that encodes a protein resembling the C-terminal region of Cet1. Accordingly, we designated this gene CTL1 (capping enzyme RNAtriphosphatase-like 1). CTL1 is not essential for c...

Journal: :Cell 1995
Christopher Hug Patrick Y. Jay Indira Reddy James G. McNally Paul C. Bridgman Elliot L. Elson John A. Cooper

Actin assembly is important for cell motility, but the mechanism of assembly and how it relates to motility in vivo is largely unknown. In vitro, actin assembly can be controlled by proteins, such as capping protein, that bind filament ends. To investigate the function of actin assembly in vivo, we altered the levels of capping protein in Dictyostelium cells and found changes in resting and che...

Journal: :The Journal of Cell Biology 2004
Kyoungtae Kim Atsuko Yamashita Martin A. Wear Yuichiro Maéda John A. Cooper

The mechanism by which capping protein (CP) binds barbed ends of actin filaments is not understood, and the physiological significance of CP binding to actin is not defined. The CP crystal structure suggests that the COOH-terminal regions of the CP alpha and beta subunits bind to the barbed end. Using purified recombinant mutant yeast CP, we tested this model. CP lacking both COOH-terminal regi...

Journal: :Brazilian oral research 2006
André Luiz Fraga Briso Vanessa Rahal Sandra Rahal Mestrener Eloi Dezan Junior

Pulp capping is a procedure that comprises adequate protection of the pulp tissue exposed to the oral environment, aiming at the preservation of its vitality and functions. This study evaluated the response of the dental pulps of dog teeth to capping with mineral trioxide aggregate (MTA) or calcium hydroxide P.A. For that purpose, 37 teeth were divided into two groups, according to the capping ...

Journal: :Journal of nanoscience and nanotechnology 2014
P Taivansaikhan D Odkhuu O R Kwon N Tsogbadrakh S C Hong

We systematically investigate the effects of having Pt as a substrate and/or capping layer on the magnetism and magnetocrystalline anisotropy (MCA) of 3d transition metal (TMs; Cr, Mn, Fe, and Co) monolayers (MLs) by using a first-principles calculationl method. We found that Fe and Co MLs are ferromagnetic (FM) on a Pt(001) surface, but Mn and Cr MLs are antiferromagnetic (AFM). The magnetic m...

Journal: :The Journal of bone and joint surgery. British volume 2009
M Egermann L Döderlein E Schläger S Müller F Braatz

In patients with severe quadriplegic cerebral palsy and painful hip dislocation proximal femoral resection arthroplasty can reduce pain, but the risk of heterotopic ossification is significant. We present a surgical technique of autologous capping of the femoral stump in order to reduce this risk, using the resected femoral head as the graft. A retrospective study of 31 patients (43 hips) who h...

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