نتایج جستجو برای: carbamazepine

تعداد نتایج: 4394  

2013
Amarjot Kaur Grewal Amteshwar Singh Jaggi Avtar Chand Rana Nirmal Singh

The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of grip strength and motor coordination in Swiss albino mice. Administration of carbamazepine (16 mg/kg,...

Journal: :BMJ case reports 2014
Saeko Aizawa Takeshi Terao Koji Hatano Nobuyoshi Ishii

A 73-year-old woman outpatient with mild cognitive impairment, parasomnia and depressive state with musical hallucinations failed to respond to 400 mg/day of valproate. Once she was admitted to a university hospital, her musical hallucinations partially responded to 1 mg/day of clonazepam and sufficiently improved on 100 mg/day of carbamazepine. Two months after discharge, however, her musical ...

2017
Hisanobu Ota Yuichiro Kawamura Nobuyuki Sato Naoyuki Hasebe

We report the case of a 61-year-old man with schizophrenia who was treated with carbamazepine, in whom electrocardiography showed transient Brugada-type ST elevation. He had been hospitalized our hospital's Department of Psychiatry and had been diagnosed with pneumonia. On the following day, electrocardiography showed coved-type ST elevation in the right precordial leads and a blood examination...

2006

Star fruit juice is a potent in vitro inhibitor of CYP3A; however, few reports are available on the inhibition of CYP3A activities by star fruit juice in vivo. Therefore, in this study, we investigated the CYP3A-mediated star fruit-drug interaction in vivo. The effect of star fruit juice on carbamazepine pharmacokinetics was examined in rats. In comparison with water, the area under the concent...

Journal: :Polish journal of pharmacology 2001
J S Strzelec E Czarnecka

The effects of clonazepam (0.3 and 1.0 mg/kg or 0.1 mg/kg, b.i.d., 5 days) and carbamazepine (50 and 100 mg/kg or 12.5 and 50 mg/kg b.i.d., 5 days) on alcohol withdrawal syndrome in rats were investigated. Moreover, the influence of clonazepam (0.3 mg/kg, single dose, or repeated doses for 8 days) and carbamazepine (50 mg/kg, single dose, or repeated doses for 8 days) on the development of tole...

Journal: :Neurosciences 2014
Nazanin Razazian Maryam Baziyar Nasrin Moradian Daryoush Afshari Arash Bostani Marziyeh Mahmoodi

OBJECTIVE To evaluate the efficacy and safety of carbamazepine, pregabalin, and venlafaxine in patients with painful diabetic neuropathy (PDN). METHODS Our study was performed as a randomized, double-blind, parallel-group clinical trial between December 2012 and December 2013 at Kermanshah University of Medical Sciences, Kermanshah, Iran. Two hundred and fifty-seven patients with clinically d...

2010
Liad Mann Eliahu Heldman Yuly Bersudsky Orna Almog RH Belmaker Galila Agam

Lithium, valproate and carbamazepine decrease brain cAMP. Adenylyl-cyclase (AC), which synthesizes cAMP has nine membrane-bound isoforms (AC1-AC9). In this study we used COS7 cells transfected with cDNA of each of the isoforms to study the effect of a therapeutic concentration of each of lithium, carbamazepine and valproate on ACs activity. AC5 was the most inhibitable isoform by lithium and ca...

Journal: :Indian journal of dermatology, venereology and leprology 2009
Timir Y Mehta Laxman M Prajapati Bharti Mittal Chaitanya G Joshi Jayesh J Sheth Dinesh B Patel Dinkar M Dave Ramesh K Goyal

BACKGROUND Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-spec...

Journal: :acta medica iranica 0
behnam behnoush department of forensic medicine, tehran university of medical sciences, tehran, iran. elham bazmie department of forensic laboratory, legal medicine organization, tehran, iran. fakhroddin taghaddosinejad department of forensic medicine, tehran university of medical sciences, tehran, iran.

introduction: carbamazepine is commonly used in a variety of indications. poisoning by this drug, can lead to coma, seizures, cardiac disorders and respiratory distress. the treatment of poisoning is generally supportive. method: 68 poisoned patients with carbamazepine, who referred to poisoning ward of loghman hospital, from july 2003 to september 2004, were studied. these patients were invest...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Ann-Charlotte Egnell Brian Houston Scott Boyer

Atypical (non-Michaelis-Menten) kinetics are commonly observed with CYP3A4 substrates in vitro. If relevant in vivo, cytochrome P450 heteroactivation could give rise to increased drug clearance. To test the possible in vivo relevance of atypical cytochrome P450 kinetics, we investigated the role of heteroactivation in the therapeutically relevant drug interaction between the anti-epileptics fel...

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