Myocardial metabolism of Nembutalized normal intact dogs was studied with the aid of the coronary sinus catheterization technic. Oxygen, glucose, lactate and pyruvate were extracted by the heart in direct relation to the arterial level of each substance, independently of the others. Pyruvate and lactate showed a high myocardial extraction coefficient, but the normal low arterial levels at rest ...

In normal polymorphonuclear leukocytes the occurrence of a high rate of aerobic glycolysis with a concomitant large formation of lactic acid has been demonstrated (1, 2) and the enzymes and intermediates of the Embden-Meyerhof pathway have been isolated and identified (3-5). There are indications for the presence and activity of the Krebs cycle, but the contribution of this cycle to metabolism ...