Tetrairidium carbonyl clusters are potentially useful connectors for multidimensional functionalized frameworks with organic bis-phosphines as linkers. The reaction of Ir(4)(CO)(12) and 1,4-bis(diphenylphosphinomethyl)benzene produces an oligomeric cyclic structure, made of 4 connectors and 6 linkers, a possible intermediate in the formation of three dimensional networks.

In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring shows an envelope conformation with the N atom displaced by 0.661 (3) Å out of the plane formed by the four C atoms of the pyrrolidine ring. The dihedral angle between this plane and the plane formed by the four attached C atoms of the piperidine ring (not including the c...

In the title complex, [Ni(C(14)H(12)N(3)O)(2)], the Ni(II) atom lies at the centre of a distorted octahedron formed by two tridentate hydrazone ligands. Inter-molecular hydrogen bonds of the type C-H⋯X (X = N, O) link the complexes into a two-dimensional network.

The ability to rapidly assess the preferred conformation of key fragments in a structure "by visual inspection" is a very useful starting point in the process of drug design. With the ability to do so, one could address questions like: "How could we avoid planarity in a molecule?", "Will a molecule change its conformational preference if we make it more or less basic?" or "How does this electro...

Karlman Wasserman, MD, PhD, FCCP Karlman Wasserman was born in Brooklyn, New York, in 1927. He graduated from high school in June 1944, and at the age of 17, at the height of World War II, he joined the US Army Specialized Training Reserve Program. Before he was able to complete his studies in engineering at Princeton University, he was called to active duty, serving in the postwar Army of Occu...

In the title compound, C(14)H(15)NO(6), the ethoxy-carbonyl groups adopt extended conformations. In the crystal, mol-ecules are linked into centrosymmetric dimers via pairs of C-H⋯O hydrogen bonds with a R(2) (2)(20) motif.

Department of Anesthesiology, Hospital for Special Surgery, Weill Cornell Medical College, NY 10021, USA; Department of Anesthesiology, Perioperative Medicine and Intensive Care Medicine, Paracelsus Medical University, Muellner Hauptstrasse 48, Salzburg 5020, Austria Correspondence to: Stavros G. Memtsoudis, MD, PhD, FCCP. Department of Anesthesiology, Hospital for Special Surgery, Weill Cornel...

In the title compound, C(14)H(13)NO(2), the mean planes through the benzyl and 2-hydoxybenzamide units make a dihedral angle of 68.81 (7)°. There is an intra-molecular O-H⋯O hydrogen bond involving the carbonyl O atom and the 2-hydr-oxy substituent. In the crystal structure, N-H⋯O hydrogen bonds link symmetry-related mol-ecules into one-dimensional chains extending along the a-axis direction. T...

The asymmetric unit of the title compound, C(30)H(34)N(4)O(6), contains two independent mol-ecules. In one independent mol-ecule, the two eth-oxy-carbonyl groups are each disordered over two conformations with occupancy ratios of 0.586 (2):0.414 (2) and 0.508 (2):0.492 (2). The crystal packing exhibits weak inter-molecular C-H⋯O hydrogen bonds.

In the title compound, C(7)H(10)O(7), the aliphatic chain is approximately planar [maximum deviation = 0.013 (1) Å] and makes a dihedral angle of 78.75 (7)° with the methoxy-carbonyl group. In the crystal, mol-ecules are linked via inter-molecular O-H⋯O and C-H⋯O hydrogen bonds into sheets parallel to (100). In the sheet, O-H⋯O hydrogen bonds generate R(2) (2)(9) and R(2) (2)(8) ring motifs.