Lobular carcinoma in situ (LCIS) is associated with an increased risk of breast cancer and accounts for 1 to 2% of all breast cancers. LCIS diagnosis currently remains one of the major identifiable risk factors for subsequent breast cancer development. Imaging methods are becoming increasingly sensitive, and the consequent detection of small lesions and subtle abnormalities increases the chance...

The title compound, cis-[Re(C(12)H(24)O(4)P)Cl(2)O(C(18)H(15)P)], was prepared from the analogous trans isomer [Głowiak et al. (2000 ▶). Polyhedron, 19, 2667-2672] by a trans-cis isomerization reaction. The Re(V) atom adopts a distorted octa-hedral coordination geometry. Besides being coordinated by the oxide and the butano-late O atoms, the Re(V) atom is coordinated by a pair of chloride ligan...

In silico veritas? Maybe not the whole truth, but very helpful suggestions and guidelines for the experimental work can be deduced from computational studies on Rh-catalyzed [3+2+1] cycloaddition reactions for the construction of cis-fused bicyclohexenones from alkylidenecyclopropanes and carbon monoxide.

The quantitative measurements used to express the rate of occurrence of disease and the magnitude of its accumulation are, respectively, incidence and prevalence. Incidence is the number of cases of a disease being produced by a population over time and is expressed as a rate of production per unit of time per unit of population. Prevalence, on the other hand, is the number of persons in the po...

The need for informed consent is considered from the patient's viewpoint by an examination of the shortcomings of the UK Ductal Carcinoma In Situ (DCIS) trial and its failure satisfactorily to accrue both profession and patient. The impersonal, negative aspects of the informed consent process in the research situation are contrasted with the positive benefits of confidence fostered by the tradi...

however, as the eye lies within the orbit which is a closed anatomical funnel, symptoms can include exopthalmos or globe displacement. Acute exacerbations, such as pain and exopthalmos can effectively be treated with radiotherapy or systemic treatment which leads to symptomatic improvement, as was the case in this patient. She successfully tolerated six cycles of single-agent Epirubicin followe...

Semi-empirical energy calculations for an internal Pro-Pro dimer are presented that take into account the nature of the flexibility of the proline ring due to its puckering. Calculations show that three stable conformations are available for the dimer: the cis (w = O", + = 160'); the trans (w = 180", $ = 160", also referred to as trans'); and the cis' (w = 180°, tb = -40') conformations. The be...

The synthesis, NMR characterization, and X-ray crystallography of "lantern-shaped" platinum(III) complexes with four pivaloamidate bridging ligands and two 9-ethylguanines (9-EtG) or 1-methylcytosines (1-MeC) in axial positions are reported: cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(9-EtG)(2)](NO(3))(2) and cis-N(2)O(2)-[Pt(2){HN=C(Bu(t))O}(4)(1-MeC)(2)](NO(3))(2). The last complex is, to the best o...

In the title complex, [PtCl2(C6H16N2)], the Pt(II) atom adopts a distorted cis-PtN2Cl2 square-planar coordination geometry. The five-membered chelate ring adopts a twisted conformation. In the crystal, weak C-H⋯Cl hydrogen bonds link the mol-ecules into (001) sheets.

Substitutive arylation of cis-allylic diols occurs upon treatment with arylboroxines in the presence of a rhodium(I) catalyst; the reaction proceeds through the addition of an intermediate arylrhodium(I) species across the carbon-carbon double bond and subsequent beta-oxygen elimination.