AIMS current criteria for cardiac resynchronization therapy (CRT) are restricted to patients with a wide QRS complex (>120 ms). Overall, only 30% of heart failure patients demonstrate a wide QRS complex, leaving the majority of heart failure patients without this treatment option. However, patients with a narrow QRS complex exhibit left ventricular (LV) mechanical dyssynchrony, as assessed with...

et al. The impact of myocardial viability on the clinical outcome of cardiac resynchronization therapy. et al. Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony. et al. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients.plantati...

BACKGROUND Cardiac resynchronization therapy improves mortality and morbidity in patients with heart failure (HF) with wide QRS complex and diminished left ventricular (LV) function, but response is variable. METHODS AND RESULTS The Speckle Tracking Assisted Resynchronization Therapy for Electrode Region (STARTER) was a prospective, double-blind, randomized controlled trial testing the hypoth...

Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system (CSP), has emerged as a strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT HF CPP pacemaker HF, patien...

background: despite several reports regarding the use of the occlutech figulla® flex septal occluder (offso) in adults, there are few reports on its use in children. we sought to study the result of the transcatheter closure of atrial septal defect (asd) using the offso in children ≤ 12 years. methods: w e enrolled 45 consecutive patients, ranging from 2.5 to 12 years of age, in two large pedia...

CONTEXT AND OBJECTIVE Cardiac resynchronization therapy (CRT) has emerged as the predominant electrical treatment strategy for patients on pharmacological therapy who present heart failure with wide QRS and low ejection fraction. The objective of this study was to investigate whether cardiac resynchronization therapy improved mortality and morbidity among patients with heart failure. METHODS ...

A 69-year-old woman with idiopathic dilated cardiomyopathy and chronic heart failure experienced repeated hospital admissions for acute pulmonary edema with no recognizable precipitating factor. Worsening mitral regurgitation was triggered by exercise echocardiography and significant intraventricular dyssynchrony was elicited by low-dose dobutamine stress echocardiography. After cardiac resynch...

In the current issue of Circulation, Anand and colleagues representing the COMPANION (The Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) Investigators have brought forward compelling data that emphasize the substantial morbidity benefit of cardiac resynchronization therapy (CRT) in patients with moderately severe to severe heart failure. Unlike other studies that hav...