OBJECTIVE To compare the similarities among the multimorbidity patterns identified in primary care patients from two European regions (Spain and the Netherlands) with similar organisational features of their primary care systems, using validated methodologies. METHODOLOGY This observational, retrospective, multicentre study analysed information from primary care electronic medical records. Mu...

Premature declines in function among adults with cerebral palsy (CP) are generally attributed to weakness, spasticity and orthopaedic abnormalities, as well as chronic pain and fatigue. Very little research or clinical attention has been devoted to the confluence and consequences of early muscle wasting and obesity as mediators of secondary comorbidity in this population, and perhaps more impor...

Healthy longevity is a tangible possibility for many individuals and populations, with nutritional and other lifestyle factors playing a key role in modulating the likelihood of healthy ageing. Nevertheless, studies of effects of nutrients or single foods on ageing often show inconsistent results and ignore the overall framework of dietary habits. Therefore, the use of dietary patterns (e.g. a ...

background: excess serum uric acid (ua) accumulation can lead to various diseases. increasing evidences reveal that ua may have a key role in the pathogenesis of metabolic syndrome. little is known about the associations of ua levels with cardiometabolic risk factors in prediabetic individuals. this study was designed to evaluate the association between ua and cardiometabolic risk factors in pr...

We thank Polesel et al for their comments on our study (1) and agree that the relation between obesity and cardiometabolic risk factors is modulated by comorbidities and/or by medications for treating chronic diseases. In this context, as rightly pointed out, sleep disorders are known to be associated with cardiometabolic abnormalities, and because sleep-disordered breathing is more common in o...

cardiovascular disease (cvd) is the driving force behind the discrepancy in life expectancy between indigenous and nonindigenous groups in many countries. preceding cvd many indigenous groups exhibit a cluster of cardiometabolic risk factors, including overweight-obesity, diabetes, high cholesterol, and high blood pressure. in turn, modifiable lifestyle risk factors contribute to the developmen...

BACKGROUND A concept referred to as locomotive syndrome (LS) was proposed by the Japanese Orthopaedic Association in order to help identify middle-aged and older adults who may be at high risk of requiring healthcare services because of problems associated with locomotion. Cardiometabolic disorders, including obesity, hypertension, diabetes, and dyslipidemia, have a high prevalence worldwide. T...

Evidence from epidemiological, clinical, and experimental studies have clearly shown that disease risk in later life is increased following a poor early life environment, a process preferentially termed developmental programming. In particular, this work clearly highlights the importance of the nutritional environment during early development with alterations in maternal nutrition, including bo...

Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a prom...

We investigated the role of microRNAs (miRNA) in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus (T2DM). miR-29 was dysregulated in resistance arterioles obtained by biopsy in T2DM patients. Intraluminal delivery of miR-29a-3p or miR-29b-3p mimics restored normal endothelium-dependent vasodilation (EDVD) in T2DM arterioles that otherwi...