Animal studies show efficacy of intravenous lipid emulsion in the treatment of severe cardiotoxicity associated with local anesthetics, clomipramine, and verapamil, possibly by trapping such lipophilic drugs in an expanded plasma lipid compartment ("lipid sink"). Recent case reports describe lipid infusion for the successful treatment of refractory cardiac arrest caused by parenteral administra...

Accidental hypothermia is an acute medical emergency with a high mortality rate. Physiologic derangements include hypoxemia, hypotension, acidosis, and arrhythmias. Management consists of careful monitoring rewarming, vigorous supportive care, and treatment of underlying and complicating disorders. Active core rewarming is recommended for hypothermia with associated cardiovascular insufficiency...

A thiamine deficient patient presented to the emergency department with an acute confusional state, becoming unconscious and hypotensive following the administration of 32 g of intravenous glucose over 4 hr. A dramatic clinical improvement in his cardiovascular and neurological status followed a single intra-venous dose of 250 mg of thiamine. Profound thiamine deficiency was confirmed on bioche...

The early mortality in pulmonary embolism (PE) is largely predicted by the associated cardiovascular response, with progressive right ventricular failure, hypotension, shock, and circulatory arrest being associated with increasing mortality. Thrombolysis may improve the prognosis of PE associated with these varying degrees of circulatory collapse, but has no place in the treatment of small embo...

The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation. Major changes occur in the cardiovascular, pulmonary, endocrine, and immunological systems, and, if untreated may soon result in cardiovascular collapse and somatic death. Understanding these complex physiologic changes is mandatory for developing effective strategies for don...

AIM Based on previous observations of strain-related alterations in sensitivity to anesthetics, this study used a newly established genetic rat model to identify differences in cardiovascular sensitivity to the commonly used, clinically relevant, anesthetic propofol and to correlate such differences with specific chromosomal substitutions. METHODS Cardiovascular sensitivity to propofol was co...

Although several studies have investigated the effect of degradation on the behavior of structures, investigations on collapse margin ratios are rare in the literature. In this study, the effect of strength and stiffness degradation on collapse capacity of steel moment frames is investigated. The aim is to determine margin of safety against collapse using a probabilistic approach. For this reas...

The answer may be yes. A discrete model of energy-conserved wavefunction collapse is proposed. It is shown that the model is consistent with existing experiments and our macroscopic experience.