The inhibitory effect of manidipine, a long acting calcium channel blocker, on vascular smooth muscle cell proliferation was investigated in spontaneously diabetic GK rats with balloon catheter-induced denudation of the carotid artery. Treatment with manidipine at doses of 4.6 and 15.1 mg/kg/day inhibited thickening of the neo-intima in the balloon catheter-injured artery without any effect on ...

Introduction: In this study, a non-invasive method based on consecutive ultrasonic image processing is introduced to assess time rate changes of the carotid artery wall displacement, velocity and acceleration in the longitudinal direction. The application of these parameters to discriminate healthy and atherosclerotic arteries was evaluated. Methods: Longitudinal displacement rate of common car...

Carotid artery stenting (CAS) is emerged as a safe and cost-effective treatment of carotid artery (CA) stenosis [1]. However the long-term efficacy of CAS is under clinical evaluation and, in particular, the role of in-stent restenosis (ISR) is not clear. More data and dedicated studies are necessary to elucidate the mechanisms of ISR and their relation with the novel carotid stent designs. Exp...

permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Previous studies have reported stroke magnetic resonance imaging (MRI) assessments that included a carotid magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) sequence. The findings of these studies showed that a carotid MPRAGE-positive signal was...

The results for blood flow in the carotid artery bifurcation on the basis of numerical simulation of Navier-Stokes equations are presented in this study. Four cases of carotid bifurcation are considered: common carotid artery (CCA) bifurcation without stenoses and cases with one, two and three stenoses are also presented. The results are obtained by performing numerical simulations considering ...

BACKGROUND Large vessel vasculitis is a rare disorder usually occurring in the context of the autoimmune conditions of giant cell arteritis and Takayasu's arteritis. Case reports have described large vessel vasculitis occurring in individuals with myelodysplastic syndrome, preceding transformation to acute myeloid leukemia. CASE PRESENTATION A 56-year-old Afghanistan-born woman presented with...

 Introduction: Prevalence of stroke following coronary artery bypass graft surgery (CABG) is % 2.1-5.2 and associated with high mortality. The purpose of this study was to investigate the prevalence of carotid artery disease in patients undergoing CABG surgery.  Methods: This cross-sectional study was performed in the years 2010-2011 on 192 patients who underwent open heart surgery (CABG) in...

Shear-induced migration of red blood cells (RBCs) is a well-known phenomenon characterizing blood flow in the small vessels (micrometre to millimetre size) of the cardiovascular system. In large vessels, like the abdominal aorta and the carotid artery (millimetre to centimetre size), the extent of this migration and its interaction with secondary flows has not been fully elucidated. RBC migrati...

Spontaneous dissections of the extracranial internal carotid artery are diagnosed more frequently as their clinical and angiographic features are more widely recognized. Familial occurrence of spontaneous dissection of the internal carotid artery has not been previously reported. We describe the occurrence of this entity in a mother and daughter and also in a father and son. The familial occurr...