Centrosomes are key microtubule-organizing centers that contain a pair of centrioles, conserved cylindrical, microtubule-based structures. Centrosome duplication occurs once per cell cycle and relies on templated centriole assembly. In many animal cells this process starts with the formation of a radially symmetrical cartwheel structure. The centrosomal protein Cep135 localizes to this cartwhee...

From left to right and from top bottom: 1. The Stephan's Quintet (interacting galaxies' group), 40 million 290 light-years away; 2. Cartwheel Galaxy, a merger of galaxies 144,300 across, 500 3. spectrum the exoplanet WASP-96b (1,150 away), showing evaporated water; 4. James Webb telescope in its clean room; 5. South Ring Nebula, 2,500 away (12 across); 6. Galactic cluster early universe SMACS 0...

Background: Recently, the rate of antibiotic resistance Campylobacter has been reported to be increasing and mechanism this related activity efflux pumps. The purpose study was isolate strains from domestic animals such as poultry cows evaluate role pumps in property them. Methods: A total 300 fecal samples were collected subjected isolation by preT-KB method. isolates identified confirmed phen...

BACKGROUND STIL is a centriole duplication factor that localizes to the procentriolar cartwheel region, and mutations in STIL are associated with autosomal recessive primary microcephaly (MCPH). Excess STIL triggers centriole amplification, raising the question of how STIL levels are regulated. RESULTS Using fluorescence time-lapse imaging, we identified a two-step process that culminates in ...

BACKGROUND Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid l...

Formation of a new centriole adjacent to a pre-existing centriole occurs only once per cell cycle. Despite being crucial for genome integrity, the mechanisms controlling centriole biogenesis remain elusive. Here, we identify RBM14 as a novel suppressor of assembly of centriolar protein complexes. Depletion of RBM14 in human cells induces ectopic formation of centriolar protein complexes through...

The Cartwheel is one of the most outstanding examples of a dynamically perturbed galaxy where star formation is occurring inside the ring–like structure. In previous studies with Chandra, we detected 16 Ultra Luminous X-ray sources lying along the southern portion of the ring. Their Luminosity Function is consistent with them being in the high luminosity tail of the High Mass X-ray Binaries dis...

How centrioles and basal bodies assemble is a long-standing puzzle in cell biology. To address this problem, we analyzed a novel basal body-defective Chlamydomonas reinhardtii mutant isolated from a collection of flagella-less mutants. This mutant, bld10, displayed disorganized mitotic spindles and cytoplasmic microtubules, resulting in abnormal cell division and slow growth. Electron microscop...

AMPA receptors mediate rapid glutamatergic synaptic transmission. In the mammalian cochlear nuclei, neurons receive excitatory input from either auditory nerve fibers, parallel fibers, or both fiber systems. The functional correlates of differences in the source of input were examined by recording AMPA receptor-mediated, miniature EPSCs (mEPSCs) in whole-cell voltage-clamp mode from identified ...