An efficient manganese(II)/O2-promoted oxidative radical cascade reaction was developed for the modular synthesis of multi-substituted isoquinolines from easily accessible vinyl isocyanides and boronic acids.

Cascade reactions provide a straightforward access to many valuable compounds and reduce considerably the number of steps synthetic sequence. Among domino multicomponent processes that involve alkynes, cascade reaction between alkynoic acids C-, N-, O- S-aminonucleophiles stands out as particularly powerful tool for one-pot construction libraries nitrogen-containing heterocyclic with scaffold d...

The largest perturbation on upper trophic levels of many marine ecosystems stems from fishing. The reaction of the ecosystem goes beyond the trophic levels directly targeted by the fishery. This reaction has been described either as a change in slope of the overall size spectrum or as a trophic cascade triggered by the removal of top predators. Here we use a novel size- and trait-based model to...

An efficient organocatalytic Michael-aldol cascade reaction for the asymmetric synthesis of spirocyclic oxindole derivatives fused with tetrahydrothiophenes has been developed through a formal [3+2] annulation strategy.

A three-component reaction of indoles, sulfonyl azides and terminal alkynes afforded 3-functionalized indoles in a single step via copper-cascade catalysis.

A facile and flexible approach for the preparation of macrocyclic molecules containing different carbohydrate moieties is presented, employing the reaction cascade: click-dimerization and ring-closing metathesis.

The first example of a palladium-catalyzed multi-cascade reaction by simple cycloenes with aryl halides in a single operation to furnish five-contiguous-stereocenter hydronaphthoindolones is described.

Reactions of diphenylphosphinoyl radicals with 5-aryl-2-pentenoates or β-phenylethylene styrenes generate trans-substituted tetrahydronaphthalenes through a cascade reaction sequence.

A modular approach to 3-substituted 2-quinolones via a cascade annulation reaction between 4-nitroketones and hydrazines has been developed.

[reaction: see text] A synthetic approach toward the immunosuppressants SNF3345 C and SNF4435 D featuring a tandem Stille coupling/electrocyclization cascade is described.