Evidence from knockout studies in male mice and from experiments in male rats, in which expression of the estrogen receptor alpha (ERα) gene was inhibited in the medial preoptic area (MPO), suggests that ERα is important in the control of male rat mating behavior. Therefore, in this experiment, we tested the hypothesis that activation of ERα in the MPO is sufficient to maintain mating behavior ...

Nigrostriatal damage is increased in males relative to females. While estrogen is neuroprotective in females, less is known about potential protective effects of testosterone in males. We determined if castration enhances neuronal injury to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Castrates or sham-castrated mice were sacrificed 1 week following injection of MPTP (4 × 20 mg/kg) or s...

conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

Recent work by Woolley, Fekete, and Little (6, 8) has demonstrated that in certain inbred strains of mice striking changes in the adrenal cortex follow early castration. The female mice of the dilute brown (Dba) strain, castrated at birth, showed areas of nodular hyperplasia in the adrenal cortex, after one year involving and partly replacing all three zones of the cortex. These mice also showe...

Androgen receptor (AR) plays a critical role in bladder cancer (BCa) development. Our early studies found AR knock-out mice (with few androgens and deleted AR) failed to develop BCa, yet 50% of castrated mice (with few androgens and existing AR) still developed BCa in an N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) carcinogen-induced BCa mouse model, suggesting the existing AR in BCa of castrate...

Castration of male animal's leads to a reduction in aggressive behavior, which animals will avoid wasting energy resulting to economic production of the animal, grows. It also reduces damage and bruising animals and increases normed meat producing at slaughter. In this study, 20 lambs Ghezel breed in four age groups, group 1: one month (n = 4), group 2: two months (n = 4) Group 3: three months ...

Incorporation of 32p into RNA and DNA fractions of mammary and tumor tissue was studied in virgin C3H mice, which are susceptible to the development of breast cancer. Virgin C57BL mice, which are resistant to the development of breast cancer, were the controls. Virgin C3H and C57BL mice, 4 and a months old, and tumor-bearing C3H mice were used as the experimental groups. The incorporation of 32...

This study aimed to investigate the immunological mechanisms involved in the gender distinct incidence of paracoccidioidomycosis (pcm), an endemic systemic mycosis in Latin America, which is at least 10 times more frequent in men than in women. Then, we compared the immune response of male and female mice to Paracoccidioides brasiliensis infection, as well as the influence in the gender differe...

Tribulus terrestris (TT) has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behaviour and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of TT containing protodioscin (PTN) as an aphrodisiac. Adult Spragu...

Muscle-derived stem cells (MDSCs) are known to exhibit sexual dimorphism, by donor sex, of osteogenic, chondrogenic, and myogenic differentiation potential in vitro. Moreover, host sex differences in the myogenic capacity of MDSCs in vivo are also observed. This study investigated the role of host sex and host sex hormones in MDSC-mediated bone formation and healing. Using unaltered male, castr...