Immunomodulatory drugs (IMiDs) are potent inhibitors of TNFand IL-1 and elevators of IL-10 production in LPS-stimulated human PBMC. They are currently in clinical trials for various diseases, including multiple myeloma, myelodysplastic syndrome, and melanoma. In the present study, we have investigated the eVects of thalidomide, CC-5013 and CC-4047 on the expression of COX-2 by stimulated PBMC. ...

Building a computationally creative system is a challenging undertaking. While such systems are beginning to proliferate, and a good number of them have been reasonably well-documented, it may seem, especially to newcomers to the field, that each system is a bespoke design that bears little chance of revealing any general knowledge about CC system building. This paper seeks to dispel this conce...

The development of silicone prostheses for augmentation of the calf and buttocks has led a small number of our patients to consider the use of implants for aesthetic thigh augmentation. In this article, we report a new thigh augmentation technique using submuscular placement of silicone gel-filled implants. Fresh cadaver dissections were performed to measure the space between the gracilis muscl...

In this article, we tackle the problem of compiling cc(X) languages 9, 13] where X is an admissible constraint domain. The diiculty of this task consists in one) representing and optimising diierent domains X and two) providing an parallel and extensible execution model. A simple way to meet these demands is to provide a minimal parallel (and distributable) kernel language expressive enough to ...

Recently there has been mounting evidence for the existence of a cosmological constant (CC). Here we show that cosmic magnetic fields act as a CC, having negative pressure and tending to cause cosmological acceleration. However, if present-day estimates of the intensity of these fields are correct, they would be too weak to be the cause of the acceleration. It is pointed out that large-scale co...

Let $A$ be a positive (semidefinite) operator on complex Hilbert space $\mathcal{H}$ and let $\mathbb{A}=\left(\begin{array}{cc} A & O O A \end{array}\right).$ We obtain upper lower bounds for the $A$-Davis-Wielandt radius of semi-Hilbertian operators, which generalize improve existing ones. also $\mathbb{A}$-Davis-Wielandt $2 \times 2$ matrices. Finally, we determine exact value two matr...

B. Aubert, R. Barate, M. Bona, D. Boutigny, F. Couderc, Y. Karyotakis, J. P. Lees, V. Poireau, V. Tisserand, A. Zghiche, E. Grauges, A. Palano, J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu, G. Eigen, I. Ofte, B. Stugu, G. S. Abrams, M. Battaglia, D. N. Brown, J. Button-Shafer, R. N. Cahn, E. Charles, M. S. Gill, Y. Groysman, R. G. Jacobsen, J. A. Kadyk, L. T. Kerth, Yu. G. Kolomensky, G. K...

This paper presents a model for the Sprint AERCam, a beachball sized robotic camera that floats around in the cargo bay of the Space Shuttle, allowing the astronauts and ground mission control to have an additional view of the task they are trying to accomplish. It has a self contained propulsion system, giving it the capability to maneuver with six degrees of freedom. We present a model for th...

The resolution-of-the-identity (RI) approximation has placed the onus of the cost of a second-order Moller-Plesset (MP2) calculation on the underlying self-consistent field (SCF) calculation for many moderately sized molecules. A dual-basis approach to the SCF calculation, based on previous methods demonstrated for density functional theory, is combined with RI-MP2 calculations, and small basis...