Different plasma membrane receptors are internalized through saturable/noncompetitive pathways, suggesting cargo-specific regulation. Here, we report that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). TTP interacts with endocytic proteins, including clathrin, dynamin, and the TfR, and localizes selectively to TfR-containing...

Classical single-factor comparable company valuation (CCV) like e.g. valuation using the price-earnings ratio is associated with several shortcomings. The two most important are the non-applicability of negative values in the basis of reference and the high requirements to the qualitative characteristics of comparable companies. This paper develops a multi-factor CCV model based on substance an...

Many Lactobacillus strains have been promoted as good probiotics for the prevention and treatment of diseases. We engineered recombinant Lactobacillus casei, producing biologically active canine granulocyte macrophage colony stimulating factor (cGM-CSF), and investigated its possibility as a good probiotic agent for dogs. Expression of the cGM-CSF protein in the recombinant Lactobacillus was co...

O tema da variação linguística, correspondendo à paramétrica na sintaxe, não tem sido explorado de modo compreensivo abordagem minimalista (veja-se, no entanto, ROBERTS, 2019 e as referência lá citadas). Duas visões centrais parcialmente distintas linguística nesse arcabouço são: (i) a se origina léxico (a chamada conjectura Borer-Chomsky, cf. BAKER, 2008) (ii) reside externalização Berwick-Cho...

The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting that it is optimized to achieve the appropriate levels of cargo and lipid internalization. The three most abundant proteins in mammalian endocytic CCVs are clathrin and the two cargo-selecting, clathrin adaptors, CALM and AP2. Here we demonstrate that depletion of CALM causes a substantial increase in the ra...

Changes in gene and genotypic frequencies at four esterase loci were monitored over 25 generations in Composite Cross V, an experimental population of barley, to obtain experimental evidence concerning the balance of forces responsible for: (1) the marked differences in allelic frequencies among barleys from different ecogeographical regions of the world; and (2) the extensive allelic variation...

Abstract A combined numerical and experimental investigation is carried out to analyze the cycle-to-cycle variations (CCV) in an optically accessible spark-ignition engine with port fuel injection. stable unstable operating condition considered. Well-established turbulence, combustion, ignition models are employed large-eddy simulations (LES). High-speed measurements of velocity field via parti...

Clathrin-coated vesicles (CCV) mediate protein sorting and vesicular trafficking from the plasma membrane and the trans-Golgi network. Before delivery of the vesicle contents to the target organelles, the coat components, clathrin and adaptor protein complexes (APs), must be released. Previous work has established that hsc70/the uncoating ATPase mediates clathrin release in vitro without the re...

Cette étude examine comment procèdent les enfants en situation d’écriture inventée, lors d’une même passation, considérant tant le nombre de lettres produites pour chaque mot que unités orales auxquelles ces correspondent. À l’encontre l’hypothèse courante selon laquelle procèderaient à un moment donné façon unitaire (par exemple syllabique ou phonémique) et uniforme (quel soit l’objet écrire),...