نتایج جستجو برای: cd200
تعداد نتایج: 528 فیلتر نتایج به سال:
Murine plasmacytoid dendritic cells (pDCs) have been credited with a unique ability to express indoleamine 2,3-dioxygenase (IDO) function and mediate immunosuppression in specific settings; yet, the conditions of spontaneous versus induced activity have remained unclear. We have used maneuvers known to up-regulate IDO in different cell types and have examined the relative efficacy and mechanism...
زمینه و هدف: یکی از عوامل اصلی پاتوژنز و پیشرفت aml به عنوان یک بدخیمی سیستمیک، نقص در پاسخ های ایمنی از طریق افزایش عملکردهای تنظیمی و مهاری است که می تواند به عنوان یکی از اهداف ایمونوتراپی در درمان این بیماران مورد استفاده قرار گیرد. افزایش بیان مولکول cd200 به عنوان یک مولکول سرکوبگر ایمنی و آنزیم مهار کننده پاسخ های ایمنی به نام اندول آمین 2 و 3 دی اکسیژناز در برخی از سرطان ها و بدخیمی ها...
BackgroundCD200-CD200R plays a critical role in regulating the human tumor microenvironment, but its cervical cancer remains unclear.MethodsA total of 62 paraffin blocks tissues were collected from patients. Expression CD200 and cathepsin K (CTSK) para-cancerous was analyzed by immunohistochemistry. Stably transfected cells established HeLa SiHa cells. Human THP-1 monocytes induced to different...
CD200 is a transmembrane molecule with an important immunoregulatory role that is overexpressed on most chronic lymphocytic leukemia (CLL) cells. In this study, we characterized a previously unknown soluble form of this molecule in human plasma termed sCD200. Levels of sCD200 were elevated in the plasma of patients with CLL as compared with healthy controls, and there was a significant correlat...
CD200R is an immune receptor of the IgG family that primarily expressed on cells myeloid lineage and was recently identified as a marker for Th2 biology (Blom et al 2017). In vivo studies with knockout mice either or its ligand, CD200, have demonstrated it inhibitory capable negatively regulating responses. Previous work using agonistic antibodies to mouse showed inhibition mast cell activation...
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