BACKGROUND Angiogenesis plays a role in the progression of osteosarcoma, as well as in other mesenchymal tumors and carcinomas, and it is most commonly assessed by vascular endothelial growth factor (VEGF) expression or tumor CD31-positive microvessel density (MVD). Tumor VEGF expression is predictive of poor prognosis, and chemotherapy can affect the selection of angiogenic pattern. The aim of...

Background: Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality world - wide. Liver biopsy is the gold standard method to assess presence fibrosis , useful in determining staging severity hepatic injury. To interpret biopsies, Reticulin stain, CD31,an immunohistochemical marker, which plays an important role degree disease, were used evaluation it. Methods: 50 Disease...

OBJECTIVES The aim of this study was to evaluate the expression of MIB-1, BCL-2, VEGFR3, and CD31 and their associations with long-term survival in patients with renal cell cancer (RCC). PATIENTS AND METHODS This study consisted of 224 RCC patients who underwent radical nephrectomy from 1985 to 1995. Follow-up continued for up to over 20 years. MIB-1 and BCL-2 expression were analyzed alone, ...

We aimed to determine if chronic endurance-exercise habits affected redox status and paracrine function of CD34(+) and CD34(-)/CD31(+) circulating angiogenic cells (CACs). Subjects were healthy, nonsmoking men and women aged 18-35 yr and categorized by chronic physical activity habits. Blood was drawn from each subject for isolation and culture of CD34(+) and CD34(-)/CD31(+) CACs. No difference...

BACKGROUND Astrogliomas are the most common primary brain tumor. Its progression is the result of activation of oncogenes, inactivation of tumor suppressor genes (TSGs), and expression of various growth factors. The angiogenesis and p53 in astrogliomas play an important role in its grading, treatment strategies, and hence its clinical outcome. OBJECTIVES To analyze the frequency of presentati...

Liver cancer is an aggressive disease with a poor outcome. Here, we implicate the roles of arsenic trioxide (As2O3) and Ginsenoside Rg3 (GRg3) in VX2 carcinoma model of rabbits through CD31 and vascular endothelial growth factor (VEGF). Rabbits VX2 liver cancer models were established, then 24 rabbits were randomly divided into 3 groups with the same number (As2O3, GRg3 and control). Liver func...

BACKGROUND/AIM Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. MATERIALS AND METHODS Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity leve...