This study investigated the possible correlation between the degree of hearing impairment caused by neonatal purulent meningitis and the levels of CD64 and PCT in cerebrospinal fluid of patients, and assessed the prognostic value of such levels. We recorded data from 156 cases of neonatal purulent meningitis retrospectively. All the patients received brainstem response audiometry, and cerebrosp...

The damage-associated molecular-pattern S100A9 is found at inflammatory sites in infections and various autoimmune diseases. It is released at very high concentrations in the extracellular milieu by activated neutrophils and monocytes in response to various agents. This proinflammatory protein is found in infected mucosae and tissue abscesses where it acts notably as a potent neutrophil activat...

Clinically relevant differences between therapeutic antibodies against the same target may relate to their unique molecular attributes. Differences in profile across domains of psoriatic disease guselkumab (GUS) and risankizumab (RIS) have been observed. To explore potential mechanisms underpinning this, we studied GUS, a fully human IgG1 specific for IL-23 with native Fc region, RIS, humanized...

Stålhammar, M. 2016. Neutrophil Chemotaxis and Respiratory Burst in Term and Preterm Newborn Infants. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1265. 47 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9722-4. Neutrophil activation is the most important initial immune defense against invading microbes in newborn infants. The reduced neutro...

OBJECTIVE To assess the functional status of the IL-15/IL-15Ralpha cytokine system in different leucocyte subsets from patients with systemic lupus erythematosus (SLE). METHODS Eighteen patients with SLE (10 with inactive and eight with active disease) and 14 healthy individuals were studied. Serum levels and in vitro production of IL-15 were determined. In addition, the expression of IL-15 r...

OBJECTIVES To investigate infiltrated cells in the synovial fluid (SF) of inflamed joints of patients with rheumatoid arthritis (RA), with special reference to polymorphonuclear neutrophils (PMN) and their interaction with T cells. METHODS Expression on PMN of activation associated receptors CD14, CD64, CD83, and major histocompatibility complex (MHC) class II was examined in the SF of 15 pat...

OBJECTIVE Adenoids with obstructive hypertrophy (AH) are considered to be one of the most ancient and common problems in Paediatrics. This study aimed at investigating the expression of CD 64 on monocytes in children who had to undergo adenoidectomy. METHODS Therefore, 66 children (24 females, 42 males, mean age 4.9 years), affected by AH and requiring adenoidectomy (54%) or adeno-tonsillecto...

Clinically relevant differences amongst therapeutic antibodies against the same target may relate to their unique molecular attributes. Differences in profile across domains of psoriatic disease between guselkumab (GUS) and risankizumab (RIS) have been observed. To explore potential mechanisms underpinning this, we studied GUS, a fully human IgG1 specific for interleukin (IL)-23 with native Fc ...