Sepsis is almost invariably associated with haemostatic abnormalities ranging from subclinical activation of blood coagulation (hypercoagulability), which may contribute to localized venous thromboembolism, to acute disseminated intravascular coagulation ( characterized by massive thrombin formation and widespread microvascular thrombosis, partly responsible of the multiple organ dysfunction sy...

Arterial thrombosis and thrombus extension involve the overlapping systems of endothelial cell reactivity, platelet function, and coagulation. Thrombotic cerebrovascular occlusions arise secondary to thromboembolism from more proximal sites, e.g., the heart and proximal internal carotid artery, or from in situ thrombosis. Thrombus generation and extension involve thrombin-mediated fibrin format...

The crucial role of cell signaling in hemostasis is clearly established by the action of the downstream coagulation protease thrombin that cleaves platelet-expressed G-protein-coupled protease activated receptors (PARs). Certain PARs are cleaved by the upstream coagulation proteases factor Xa (Xa) and the tissue factor (TF)--factor VIIa (VIIa) complex, but these enzymes are required at high non...

Aims. To compare an impact of retransfusion of blood processed in cell-saver (CS) with that of cardiopulmonary bypass (CPB) on blood coagulation in patients undergoing cardiac surgery. Methods. Prospective observational study using thromboelastography (TEG). Results. TEG samples from 170 patients were analyzed. Cardiopulmonary bypass was used in 100 patients while 70 patients were operated off-...

it has been recognized that patients with cyanotic congenital heart disease (cchd) show significant bleeding tendency which can be secondary to coagulopathies in these patients. some coagulation abnormalities are thrombocytopenia, factor deficiencies, fibrinolysis and disseminated intravascular coagulation  (dic). according to high prevalence of cchd and major operations in theses patients, the...