We have previously described the inhibitory effect of interferon preparations on the multiplication of L1210 cells in vitro and presented the experimental results suggesting that interferon itself was the responsible factor (3, 4, 6) . This inhibition could be due to a decrease in the number of cells capable of dividing, to a prolongation of the cell generation time, to a decrease in the doubli...

Amenable to sophisticated genetic and molecular analysis, the simple filamentous fungus Aspergillus nidulans has provided some novel insights into the mechanisms and regulation of cell division. Mutational analysis has identified over fifty genes necessary for nuclear division, nuclear movement and cytokinesis. Molecular and cellular analysis of these mutants has led to the discovery of novel c...

Hilary A. Collera,b,* and Arshad Desaic,d aDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095; bDepartment of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095; cDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093; dLudwig Cancer Research Cente...

The recent discovery of a novel kinetochore has important implications for our understanding of the evolution of chromosome segregation systems and also for the treatment of devastating parasitic diseases.