نتایج جستجو برای: cell epitope
تعداد نتایج: 1693616 فیلتر نتایج به سال:
Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with poor response to conventional immune checkpoint inhibitors. Early data by our group suggests CD4 T cell depletion abrogates novel combination therapy that transiently curative in murine model of PDA. Given the importance cells PDA control, we now seek describe dynamics at an antigen-specific resolution. To this end, dev...
Background: The newly emerged coronavirus, SARS-CoV-2, the causative agent of COVID-19 disease, appeared in Wuhan, China December 2019 and led to death millions people. pandemic has increased demand for effective vaccines treatments worldwide. Due changes virus genome caused by mutation, variants with higher transmission ability pathogenicity have raised excessive concerns about efficiency deve...
Despite heterologous expression of epitope-tagged GPCR is widely adopted for functional characterization, there is lacking of systematic analysis of the impact of expression host and epitope tag on GPCR expression. Angiotensin type II (AT2) receptor displays agonist-dependent and -independent activities, coupling to a spectrum of signaling molecules. However, consensus has not been reached on t...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an immunodominant HLA-A2-restricted CD8 cell epitope that is frequently recognized by recovered patients. The mutation, a conservative HCV nonstructur...
Meningitis infection is one of the major threats during Hajj season in Mecca. Meningitis vaccines are available, but their uses are limited in some countries due to religious reasons. Furthermore, they only give protection to certain serogroups, not to all types of meningitis-inducing bacteria. Recently, research on epitope-based vaccines has been developed intensively. Such vaccines have poten...
background and objectives: iranian chronic hbv carrier’s population has shown a unique pattern of genotype d distri- bution all around the country. the aim of this study was to explore more details of evolutionary history of carriers based on structural surface proteins from different provinces. materials and methods: sera obtained from 360 isolates from 12 different regions of country were u...
CD4+ T cells play critical roles in initiating, regulating, and maintaining antitumor immune responses. One way to improve current tumor vaccines that mainly induce CTLs would be to activate antigen-specific CD4+ T cells that recognize MHC class II restricted tumor associated antigens. Human telomerase reverse transcriptase (hTRT) is preferentially expressed by various tumors and, therefore, co...
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